双胎动脉灌注逆转序列(TRAP):导致单胎双胎妊娠并发症的循环悖论。

Revue medicale de Liege Pub Date : 2025-04-01
Emma Cornu, Violaine Emonard
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引用次数: 0

摘要

TRAP序列(«双胞胎动脉灌注逆转序列»)是一种罕见的情况,发现约1%至3%的单绒毛膜双胞胎妊娠。这是由于正常双胞胎和心脏双胞胎(或功能不全的心脏)之间存在胎盘血管吻合(动-动脉和静脉-静脉)。然后,正常双胞胎充当“泵”,为逆行灌注的异常双胞胎提供服务。在整个怀孕期间,泵双胞胎的健康和生存受到不同机制的影响(高输出量心力衰竭、早产、胎膜早破、慢性缺氧和宫内生长迟缓)。诊断可以从妊娠第11周开始使用超声和多普勒检查脐动脉。虽然已经确定,在没有治疗的情况下,泵型双胞胎的死亡率约为50%,但目前在治疗方法和时机上没有达成共识。一些人主张在密切监测的情况下保持期待的态度。另一些人则倾向于采取干预措施,阻断流向双胞胎心脏的血液。目前使用最多的方法是激光或射频胎腔治疗。它们看起来安全有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Twin Reversed Arterial Perfusion Sequence (TRAP) : a circulatory paradox causing complications in monochorial twin pregnancies].

The TRAP sequence («Twin Reversed Arterial Perfusion Sequence») is a rare condition found in approximately 1 to 3 % of monochorionic twin pregnancies. It results from the existence of placental vascular anastomoses (arterio-arterial and veno-venous) between a normal twin and an acardiac twin (or with a dysfunctional heart). The normal twin then serves as a «pump» for the abnormal twin who is retrogradely perfused. Throughout pregnancy, the well-being and survival of the pump twin is compromised by different mechanisms (risk of high-output heart failure, premature delivery, premature rupture of membranes, chronic hypoxia and delayed intrauterine growth). The diagnosis can be made from the 11th week of gestation using ultrasound and Doppler examination of the umbilical arteries. Although it is established that the mortality of pump twins is around 50 % in the absence of treatment, there is currently no consensus on the treatment methods nor on the timing to be respected. Some advocate an expectant attitude with close monitoring. Others prefer an intervention to interrupt blood flow to the acardiac twin. Intrafetal therapies by laser or radiofrequency are the most used methods at present. They appear safe and effective.

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