慢性冠状动脉综合征的保守治疗。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-05-01 Epub Date: 2025-05-06 DOI:10.1055/a-2442-7841
Alexander Asmussen, Ingo Hilgendorf
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引用次数: 0

摘要

CCS管理基于2024年ESC指南,是当代心脏病学的基石,旨在通过保守和侵入性策略预防心血管事件,缓解症状并提高生活质量。非侵入性方法,包括患者教育、生活方式干预和优化的药物治疗,已经证明在预后和生活质量方面有显著的好处。该指南提倡以患者为中心的方法,根据病理生理机制、合并症和个人需求定制治疗方法。药理学策略包括抗血栓、降脂、raas阻断、抗炎和抗糖尿病药物,以预防事件,以及抗心绞痛药物以缓解症状。对于患有阻塞性冠状动脉疾病(如左主干疾病、三支血管疾病或LAD近端受累)或难治性心绞痛的高危患者,尽管有最佳的药物治疗,侵入性干预仍然是必要的。然而,越来越多的医疗管理的有效性日益挑战早期血运重建的增量效益。指南还强调了未被诊断的疾病,如ANOCA(非阻塞性冠状动脉心绞痛)和INOCA(非阻塞性冠状动脉缺血)。识别不同的内源性类型,包括微血管功能障碍和血管痉挛性心绞痛,可以实现精确和个性化的治疗方法。保守治疗仍然是CCS管理的基础,需要一个整体的、多学科的、以患者为中心的方法来优化结果和提高生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Conservative Management of Chronic Coronary Syndrome].

CCS management, based on the 2024 ESC Guidelines, a cornerstone of contemporary cardiology, aims to prevent cardiovascular events, alleviate symptoms, and enhance quality of life through conservative and invasive strategies. Non-invasive approaches, encompassing patient education, lifestyle interventions, and optimized pharmacological treatments, have demonstrated significant benefits in prognosis and quality of life. The guidelines advocate for a patient-centered approach, tailoring therapies to pathophysiological mechanisms, comorbidities, and individual needs. Pharmacological strategies integrate antithrombotic, lipid-lowering, RAAS-blocking, anti-inflammatory, and antidiabetic agents for event prevention, alongside antianginal medications for symptom relief. Invasive interventions remain essential for high-risk patients with obstructive coronary artery disease (e.g., left main disease, three-vessel disease, or proximal LAD involvement) or refractory angina despite optimal medical therapy. However, the growing efficacy of medical management increasingly challenges the incremental benefits of early revascularization. The guidelines also highlight underdiagnosed conditions such as ANOCA (Angina with Non-Obstructive Coronary Arteries) and INOCA (Ischemia with Non-Obstructive Coronary Arteries). Recognizing diverse endotypes, including microvascular dysfunction and vasospastic angina, enables precise and individualized therapeutic approaches. Conservative therapy remains the foundation of CCS management, demanding a holistic, multidisciplinary, and patient-centered approach to optimize outcomes and improve quality of life.

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