具有抗利什曼原虫特性的天然产物中的喹啉骨架及相关支架。

IF 3.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Frontiers in Chemistry Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.3389/fchem.2025.1571067

Gloria Yaluff, Leídi Herrera, Miriam Soledad Rolón, Celeste Vega, Hugo Cerecetto

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引用次数: 0

摘要

近一百年来，喹啉杂环一直被认为是抗利什曼原虫药物中具有优势的药效团。早期，在一些天然生物碱中发现的含有这种支架的化合物对不同阶段和菌株的利什曼原虫的作用进行了测试。在不同的体外和体内抗利什曼原虫生物碱中，已描述了含有喹啉框架的不同结构排列，即喹啉本身、异喹啉和喹诺酮等。近年来，人们从自然界中分离出新的喹啉衍生物，并进行了深入的体内外生物学研究，以及化学修饰以获得新的先导化合物。本文综述了天然喹啉类药物和一些合成衍生物的最新研究进展，为探索基于该化学系统治疗利什曼病的新药物提供了治疗工具和策略。

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The quinoline framework and related scaffolds in natural products with anti-Leishmania properties.

For almost one hundred years, the quinoline heterocycle has been recognized as a privileged pharmacophore in anti-Leishmania agents. Early on, the action of compounds with this scaffold, found in some natural alkaloids, was tested against different Leishmania stages and strains. Different structural arrangements containing the quinoline framework have been described in different in vitro and in vivo anti-Leishmania alkaloids, namely, quinoline proper, isoquinoline, and quinolone, among others. In recent years, new quinoline derivatives isolated from nature have been described, in addition to having carried out in-depth in vitro and in vivo biological studies, as well as chemical modifications to obtain new leaders. This review updates the state of the art on naturally occurring quinolines and some synthetic derivatives to provide therapeutic tools and strategies to explore new drugs based on this chemosystem for the treatment of leishmaniasis.

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来源期刊

Frontiers in Chemistry Chemistry-General Chemistry

CiteScore

8.50

自引率

3.60%

发文量

1540

审稿时长

12 weeks

期刊介绍： Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide. Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”. All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.