metacaspase和其他蛋白在利什曼原虫凋亡中的作用:综述文章。

IF 0.9 4区 医学 Q4 PARASITOLOGY
Maryam Aghaei, Shahrzad Aghaei, Zabihollah Shahmoradi, Seyed Hossein Hejazi
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引用次数: 0

摘要

背景:细胞凋亡是程序性细胞死亡(PCD)的一种确定形式,发生在多细胞和单细胞生物中。鉴于了解单细胞利什曼原虫的凋亡对制定疾病控制政策至关重要,我们对细胞凋亡机制和相关蛋白进行了综述。方法:从PubMed、SciELO、Science Direct、Scopus、谷歌Scholar和Web of Science数据库1998-2021年发表的文章中获取信息。搜索词是“细胞凋亡”或“利什曼病”。结果:共纳入77例受试者,揭示了细胞凋亡过程对利什曼原虫生存的重要意义。虽然各种刺激诱导利什曼原虫凋亡,但参与凋亡的蛋白却知之甚少。利什曼原虫的半胱天冬酶与哺乳动物的半胱天冬酶和死亡受体在PCD途径中起着相同的作用。此外,利什曼原虫的其他凋亡蛋白,如内切酶G (EndoG)、半胱氨酸蛋白酶样半胱氨酸蛋白酶、TSN (Tudor葡萄球菌核酸酶)和Zinnia内切酶1 (ZEN1),导致类似哺乳动物凋亡的表型。此外,不同种类的利什曼原虫在这些机制上存在差异,阐明与丝氨酸磷脂酰胆碱暴露、细胞色素C分泌等相关的下游事件的研究仍然是一个持续的挑战。结论:确定利什曼原虫凋亡的重要调控蛋白和metacaspase在寄生虫体内的特异性存在,有助于制定新的治疗策略和开发利什曼原虫疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Metacaspases and Other Proteins Involved in the Apoptosis of Leishmania: Review Article.

Background: Apoptosis, a determined form of programmed cell death (PCD), occurs in multi-cellular and single-celled organisms. Given that a general understanding of apoptosis in single-cell Leishmania is crucial for designing disease control policies, we reviewed the apoptosis mechanism and the proteins involved.

Methods: The information was obtained from articles published in PubMed, SciELO, Science Direct, Scopus, Google Scholar, and Web of Science databases (1998-2021). Search terms used were" apoptosis" or" Leishmaniasis".

Results: The 77 subjects were included in the study that revealed the significance of the apoptosis process for Leishmania survival. Although, various stimuli induce Leishmania apoptosis, the proteins involved in apoptosis have been poorly understood. Metacaspases in Leishmania instead of caspase and death receptors in mammals play the same role in the PCD pathways. Also, other apoptotic proteins in Leishmania such as endonuclease G (EndoG), caspases- like cysteine proteases, TSN (Tudor Staphylococcal Nuclease), and Zinnia endonuclease 1 (ZEN1) lead to phenotype similar to mammalian apoptosis. Furthermore, there are differences in these mechanisms between the different species of Leishmania and studies to illustrate downstream events related to the serine phosphatidylcholine exposure, cytochrome C secretion, etc. remain an ongoing challenge.

Conclusion: Determining the essential regulatory proteins in the Leishmania apoptosis and the specific present of metacaspases in parasite, is effective for designing new therapeutic strategies against leishmaniasis and vaccine development.

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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: Iranian Journal of Parasitology (IJP) is the official publication of Iranian Society of Parasitology (ISP) launched in 2006. The society was inaugurated in 1994 and pursues the improvement of the knowledge on the parasites and parasitic diseases, exchange of scientific knowledge with foreign societies, publicity activities, and consultation on the parasitic diseases, and intimate relationship among society members. The main aims of the Journal are: contribution to the field of Parasitology, including all aspects of parasites and parasitic diseases (medical and veterinary) and related fields such as Entomology which may be submitted by scientists from Iran and all over the world.
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