Evaluation of Tissue Annular Motion Displacement in Patients With Severe Aortic Stenosis With Normal Ejection Fraction.

Aim: The purpose of this study was to investigate the value of the tissue annular motion displacement (TMAD) parameter in assessing left ventricular systolic function in patients with severe aortic stenosis (AS) and to investigate the risk factors for major adverse cardiovascular events (MACEs) in patients with severe AS with a biplane Simpson's method ejection fraction (LVEF-Simpson) ≥ 50%.

Methods: We enrolled 81 patients diagnosed with severe AS and 22 controls. Comparative analyses were performed between the groups, and longitudinal follow-up assessments tracked the incidence of MACEs. Survival analysis, utilizing Kaplan-Meier curves, was employed to determine the prognostic significance of TMAD parameters.

Results: TMAD parameters showed negative linear correlations with left ventricle global longitudinal strain (LVGLS). Overall, 69 patients (85.2%) underwent successful transcatheter aortic valve replacement (TAVR), which significantly improves myocardial longitudinal systolic function. MACE occurred in 12 (14.8%) AS patients during the follow-up period.

Conclusion: TMAD parameters allowed early detection of left ventricle systolic dysfunction (LVSF) in severe AS patients with normal ejection fraction and correlated well with LVGLS, and TMADmid-A4C was a strong predictor of MACE in severe AS patients with preserved LVEF.