海洋分枝杆菌作为了解分枝杆菌发病原理的模型。

IF 2.7 3区生物学 Q3 MICROBIOLOGY

Journal of Bacteriology Pub Date : 2025-05-22 Epub Date: 2025-04-30 DOI:10.1128/jb.00047-25

Aruna R Menon, Rebecca J Prest, David M Tobin, Patricia A Champion

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引用次数: 0

摘要

海洋分枝杆菌是一种鱼类病原体，它已经成为一种强大而完善的模型，加速了我们对分枝杆菌疾病机制的理解。海洋分枝杆菌是了解密切相关的人类病原体结核分枝杆菌的多功能替代品，结核分枝杆菌引起人类结核病。海洋分枝杆菌已经确定了致病的关键机制，这些机制既与结核分枝杆菌共有，也为该物种所独有。在这篇综述中，我们讨论了海洋分枝杆菌作为一种偶然的人类病原体的发现，与结核分枝杆菌的发病机制的共同方面，以及海洋分枝杆菌如何被利用作为一个模型来定义分枝杆菌在感染的几个阶段的发病机制。

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Mycobacterium marinum as a model for understanding principles of mycobacterial pathogenesis.

Mycobacterium marinum is a fish pathogen that has become a powerful and well-established model that has accelerated our understanding of the mechanisms of mycobacterial disease. M. marinum is a versatile surrogate for understanding the closely related human pathogen M. tuberculosis, which causes tuberculosis in humans. M. marinum has defined key mechanisms of pathogenesis, both shared with M. tuberculosis and unique to this species. In this review, we discuss the discovery of M. marinum as an occasional human pathogen, the shared aspects of pathogenesis with M. tuberculosis, and how M. marinum has been exploited as a model to define the molecular mechanisms of mycobacterial pathogenesis across several phases of infection.

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来源期刊

Journal of Bacteriology 生物-微生物学

CiteScore

6.10

自引率

9.40%

发文量

324

审稿时长

1.3 months

期刊介绍： The Journal of Bacteriology (JB) publishes research articles that probe fundamental processes in bacteria, archaea and their viruses, and the molecular mechanisms by which they interact with each other and with their hosts and their environments.