GnRH激动剂触发对ART周期中随后卵泡期长的影响。

IF 2.7 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-01 Epub Date: 2025-05-09 DOI:10.1007/s10815-025-03503-8

Roza Berkovitz-Shperling, Yaara Libai, Shir Aviv, Ben-Yosef Dalit, Azem Foad, Feferkorn Ido

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引用次数: 0

摘要

研究问题：GnRH激动剂触发剂与hCG触发剂的使用是否会影响女性随后卵泡期的长度？设计：一项回顾性队列研究，分析了一所大学附属生育中心196名接受冷冻卵巢刺激进行PGT-M的妇女；GnRH激动剂触发132例，hCG触发64例。结果：与hCG组相比，GnRH激动剂组显示出更长的卵泡期（18.98±3.54 vs. 16.06±3.13，P）结论：与hCG相比，GnRH激动剂触发延长了随后的卵泡期，但不影响妊娠率。BMI与卵泡相长度有统计学意义，但相关性不大，有待进一步验证。这些发现对优化后续周期冷冻胚胎移植的时机具有重要意义，并可能促进更个性化的监测方案。

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Impact of GnRH agonist trigger on subsequent follicular phase length in ART cycles.

Research question: Does the use of GnRH agonist trigger versus hCG trigger affect the length of the subsequent follicular phase in women?

Design: A retrospective cohort study analyzing 196 women undergoing controlled ovarian stimulation with freeze-all for PGT-M at a university-affiliated fertility center; 132 received GnRH agonist trigger, and 64 received hCG trigger.

Results: The GnRH agonist group demonstrated a significantly longer subsequent follicular phase compared to the hCG group (18.98 ± 3.54 vs. 16.06 ± 3.13 days, P < .001), with extended follicular phase occurring in 90.2% versus 60.9% of cycles (P < .001). Both groups had comparable antral follicle counts (14.52 ± 7.71 vs. 13.00 ± 15.36, P = .748). Multiple regression analysis identified GnRH agonist trigger as a significant independent predictor of subsequent follicular phase length (coefficient = 4.552, 95% CI: 3.058-6.045, P < .001), along with BMI (coefficient = 0.188, 95% CI: 0.019-0.357, P = .030). The model explained 31.4% of the variance in follicular phase length (F = 7.516, P < .001). After adjusting for confounding variables, pregnancy rates were comparable between groups (OR = 1.763, 95% CI: 0.798-3.505, P = .173).

Conclusions: The GnRH agonist trigger prolongs the subsequent follicular phase compared to the hCG trigger without compromising pregnancy rates. BMI showed a statistically significant but modest association with follicular phase length that requires further validation. These findings have important implications for optimizing the timing of frozen embryo transfer in subsequent cycles and may facilitate more personalized monitoring protocols.

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.