Jian Liu, Linghui Kong, Binyin Zhang, Yao Yu, Zhenhe Ma
{"title":"深度相关彩色编码光学衰减系数成像：面部微循环辅助检查方法。","authors":"Jian Liu, Linghui Kong, Binyin Zhang, Yao Yu, Zhenhe Ma","doi":"10.1002/jbio.202500074","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This study investigates the relationship between facial microcirculation and optical parameters using swept-source optical coherence tomography (SS-OCT). Facial microcirculation deterioration impacts skin health by causing blood stagnation and metabolic disorders, influencing optical properties like scattering and attenuation. High-resolution SS-OCT imaging revealed distinct correlations between blood flow and optical attenuation coefficient (OAC) across skin layers: epidermal OAC showed a negative correlation with blood flow (<i>r</i> = −0.29 ± 0.03), while dermal OAC demonstrated a positive correlation (<i>r</i> = −0.43 ± 0.06). Leveraging this finding, we developed a depth-encoded color OAC imaging mode that enhances facial microcirculation visualization without additional scanning. The work provides mechanistic insights into microcirculation-related skin deterioration and establishes a novel clinical tool for diagnosing and managing associated conditions.</p>\n </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 6","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Depth-Dependent Color-Coded Optical Attenuation Coefficient Imaging: Assisted Examination Methods of Facial Microcirculation\",\"authors\":\"Jian Liu, Linghui Kong, Binyin Zhang, Yao Yu, Zhenhe Ma\",\"doi\":\"10.1002/jbio.202500074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>This study investigates the relationship between facial microcirculation and optical parameters using swept-source optical coherence tomography (SS-OCT). Facial microcirculation deterioration impacts skin health by causing blood stagnation and metabolic disorders, influencing optical properties like scattering and attenuation. High-resolution SS-OCT imaging revealed distinct correlations between blood flow and optical attenuation coefficient (OAC) across skin layers: epidermal OAC showed a negative correlation with blood flow (<i>r</i> = −0.29 ± 0.03), while dermal OAC demonstrated a positive correlation (<i>r</i> = −0.43 ± 0.06). Leveraging this finding, we developed a depth-encoded color OAC imaging mode that enhances facial microcirculation visualization without additional scanning. The work provides mechanistic insights into microcirculation-related skin deterioration and establishes a novel clinical tool for diagnosing and managing associated conditions.</p>\\n </div>\",\"PeriodicalId\":184,\"journal\":{\"name\":\"Journal of Biophotonics\",\"volume\":\"18 6\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biophotonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202500074\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202500074","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
This study investigates the relationship between facial microcirculation and optical parameters using swept-source optical coherence tomography (SS-OCT). Facial microcirculation deterioration impacts skin health by causing blood stagnation and metabolic disorders, influencing optical properties like scattering and attenuation. High-resolution SS-OCT imaging revealed distinct correlations between blood flow and optical attenuation coefficient (OAC) across skin layers: epidermal OAC showed a negative correlation with blood flow (r = −0.29 ± 0.03), while dermal OAC demonstrated a positive correlation (r = −0.43 ± 0.06). Leveraging this finding, we developed a depth-encoded color OAC imaging mode that enhances facial microcirculation visualization without additional scanning. The work provides mechanistic insights into microcirculation-related skin deterioration and establishes a novel clinical tool for diagnosing and managing associated conditions.
期刊介绍：
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.
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