Impact of the Magnetization Transfer Effect on T1 Measurements in Quantitative MR Imaging: Comparison of the Two-dimensional Multidynamic Multiecho (2D-MDME) and Three-dimensional Quantification Using an Interleaved Look-Locker Acquisition Sequence (3D-QALAS) Protocols on Two Systems.

Multiparametric quantitative MRI (MP-qMRI) methods, which measure multiple relaxation times simultaneously, are becoming into practical tools, but the relationship between different MP-qMRI methods has not been clarified. In particular, since 2D multidynamic multiple-echo (2D-MDME) was provided by multiple major MRI vendors, many patient studies have been reported, but its relationship with 3D-QALAS (3D-QuAntification using an interleaved Look-Locker Acquisition Sequence with T₂ preparation pulse), which is expected to be its 3D version successor, is unknown. In this study, we implemented 2D-MDME and 3D-QALAS on an originally designed 1.5T and a clinical 3T MRI systems, and measured relaxation times of phantoms, focusing on the effect of magnetization transfer (MT) effect on T₁ measurements. As a result, in 2D-MDME, T₁ shortening effects of around 20%-35% was observed due to the MT effect, and in 3D-QALAS, no effect of the MT effect on the T₁ measurements was observed. Therefore, we concluded that the MT effect needs to be considered when comparing MP-qMRI methods in clinical studies.