{"title":"克里米亚-刚果出血热伴脑炎的病例报告及综述:一种意外并发症。","authors":"Elham Barahimi, Elham Ouspid, Mahyar Hossein-Zargari, Masoumeh Ardeshiri, MohammadHosein Sheybani-Arani","doi":"10.1007/s13365-025-01253-y","DOIUrl":null,"url":null,"abstract":"<p><p>Crimean-Congo hemorrhagic fever is a severe tick-borne viral infection with high mortality rates. While Crimean-Congo hemorrhagic fever primarily presents as a hemorrhagic fever, central nervous system involvement, including encephalitis, is rare. The virus, transmitted through tick bites or direct contact with infected animal blood or bodily fluids, can lead to multi-organ failure. Neurological manifestations of Crimean-Congo hemorrhagic fever remain poorly understood. We report a 40-year-old man from Hormozgan province, Iran, who presented with fever, hematemesis, abdominal pain, and neurological symptoms. Initial laboratory findings indicated thrombocytopenia and elevated liver enzymes. Despite treatment with ribavirin, the patient developed agitation, confusion, and a progressive decline in consciousness. Brain imaging suggested encephalitis, and cerebrospinal fluid analysis revealed mild pleocytosis with elevated protein levels. Crimean-Congo hemorrhagic fever was confirmed via polymerase chain reaction testing. The patient was treated with ribavirin, intravenous immunoglobulin, and high-dose methylprednisolone, gradually recovering neurological function. Crimean-Congo hemorrhagic fever with encephalitis is an uncommon but severe presentation, necessitating prompt diagnosis and intervention. This case highlights the potential role of corticosteroids and intravenous immunoglobulin in managing Crimean-Congo hemorrhagic fever-associated neurological manifestations. Further studies are needed to establish standardized treatment protocols for Crimean-Congo hemorrhagic fever-related encephalitis.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"197-207"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.\",\"authors\":\"Elham Barahimi, Elham Ouspid, Mahyar Hossein-Zargari, Masoumeh Ardeshiri, MohammadHosein Sheybani-Arani\",\"doi\":\"10.1007/s13365-025-01253-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Crimean-Congo hemorrhagic fever is a severe tick-borne viral infection with high mortality rates. While Crimean-Congo hemorrhagic fever primarily presents as a hemorrhagic fever, central nervous system involvement, including encephalitis, is rare. The virus, transmitted through tick bites or direct contact with infected animal blood or bodily fluids, can lead to multi-organ failure. Neurological manifestations of Crimean-Congo hemorrhagic fever remain poorly understood. We report a 40-year-old man from Hormozgan province, Iran, who presented with fever, hematemesis, abdominal pain, and neurological symptoms. Initial laboratory findings indicated thrombocytopenia and elevated liver enzymes. Despite treatment with ribavirin, the patient developed agitation, confusion, and a progressive decline in consciousness. Brain imaging suggested encephalitis, and cerebrospinal fluid analysis revealed mild pleocytosis with elevated protein levels. Crimean-Congo hemorrhagic fever was confirmed via polymerase chain reaction testing. The patient was treated with ribavirin, intravenous immunoglobulin, and high-dose methylprednisolone, gradually recovering neurological function. Crimean-Congo hemorrhagic fever with encephalitis is an uncommon but severe presentation, necessitating prompt diagnosis and intervention. This case highlights the potential role of corticosteroids and intravenous immunoglobulin in managing Crimean-Congo hemorrhagic fever-associated neurological manifestations. Further studies are needed to establish standardized treatment protocols for Crimean-Congo hemorrhagic fever-related encephalitis.</p>\",\"PeriodicalId\":16665,\"journal\":{\"name\":\"Journal of NeuroVirology\",\"volume\":\" \",\"pages\":\"197-207\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of NeuroVirology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13365-025-01253-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of NeuroVirology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13365-025-01253-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.
Crimean-Congo hemorrhagic fever is a severe tick-borne viral infection with high mortality rates. While Crimean-Congo hemorrhagic fever primarily presents as a hemorrhagic fever, central nervous system involvement, including encephalitis, is rare. The virus, transmitted through tick bites or direct contact with infected animal blood or bodily fluids, can lead to multi-organ failure. Neurological manifestations of Crimean-Congo hemorrhagic fever remain poorly understood. We report a 40-year-old man from Hormozgan province, Iran, who presented with fever, hematemesis, abdominal pain, and neurological symptoms. Initial laboratory findings indicated thrombocytopenia and elevated liver enzymes. Despite treatment with ribavirin, the patient developed agitation, confusion, and a progressive decline in consciousness. Brain imaging suggested encephalitis, and cerebrospinal fluid analysis revealed mild pleocytosis with elevated protein levels. Crimean-Congo hemorrhagic fever was confirmed via polymerase chain reaction testing. The patient was treated with ribavirin, intravenous immunoglobulin, and high-dose methylprednisolone, gradually recovering neurological function. Crimean-Congo hemorrhagic fever with encephalitis is an uncommon but severe presentation, necessitating prompt diagnosis and intervention. This case highlights the potential role of corticosteroids and intravenous immunoglobulin in managing Crimean-Congo hemorrhagic fever-associated neurological manifestations. Further studies are needed to establish standardized treatment protocols for Crimean-Congo hemorrhagic fever-related encephalitis.
期刊介绍:
The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects.
The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.