克里米亚-刚果出血热伴脑炎的病例报告及综述:一种意外并发症。

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI:10.1007/s13365-025-01253-y
Elham Barahimi, Elham Ouspid, Mahyar Hossein-Zargari, Masoumeh Ardeshiri, MohammadHosein Sheybani-Arani
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引用次数: 0

摘要

克里米亚-刚果出血热是一种严重的蜱传病毒感染,死亡率很高。虽然克里米亚-刚果出血热主要表现为出血热,但中枢神经系统受累,包括脑炎,是罕见的。这种病毒通过蜱虫叮咬或直接接触受感染动物的血液或体液传播,可导致多器官衰竭。克里米亚-刚果出血热的神经学表现仍然知之甚少。我们报告一名来自伊朗霍尔木兹甘省的40岁男子,他表现为发烧、呕血、腹痛和神经系统症状。最初的实验室结果显示血小板减少和肝酶升高。尽管给予利巴韦林治疗,患者仍出现躁动、精神错乱和意识逐渐下降。脑成像提示脑炎,脑脊液分析显示轻度多细胞症伴蛋白水平升高。经聚合酶链反应检测确诊克里米亚-刚果出血热。患者给予利巴韦林、静脉注射免疫球蛋白和大剂量甲基强的松龙治疗,神经功能逐渐恢复。克里米亚-刚果出血热伴脑炎是一种罕见但严重的表现,需要及时诊断和干预。本病例强调了皮质类固醇和静脉注射免疫球蛋白在控制克里米亚-刚果出血热相关神经系统表现方面的潜在作用。需要进一步研究以建立克里米亚-刚果出血热相关脑炎的标准化治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case report and mini-review of Crimean-Congo hemorrhagic fever with encephalitis: an unexpected complication.

Crimean-Congo hemorrhagic fever is a severe tick-borne viral infection with high mortality rates. While Crimean-Congo hemorrhagic fever primarily presents as a hemorrhagic fever, central nervous system involvement, including encephalitis, is rare. The virus, transmitted through tick bites or direct contact with infected animal blood or bodily fluids, can lead to multi-organ failure. Neurological manifestations of Crimean-Congo hemorrhagic fever remain poorly understood. We report a 40-year-old man from Hormozgan province, Iran, who presented with fever, hematemesis, abdominal pain, and neurological symptoms. Initial laboratory findings indicated thrombocytopenia and elevated liver enzymes. Despite treatment with ribavirin, the patient developed agitation, confusion, and a progressive decline in consciousness. Brain imaging suggested encephalitis, and cerebrospinal fluid analysis revealed mild pleocytosis with elevated protein levels. Crimean-Congo hemorrhagic fever was confirmed via polymerase chain reaction testing. The patient was treated with ribavirin, intravenous immunoglobulin, and high-dose methylprednisolone, gradually recovering neurological function. Crimean-Congo hemorrhagic fever with encephalitis is an uncommon but severe presentation, necessitating prompt diagnosis and intervention. This case highlights the potential role of corticosteroids and intravenous immunoglobulin in managing Crimean-Congo hemorrhagic fever-associated neurological manifestations. Further studies are needed to establish standardized treatment protocols for Crimean-Congo hemorrhagic fever-related encephalitis.

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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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