用比色传感器定量测定三氟甲基酮水合物的给氢键能力

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-15 DOI:10.1021/acs.joc.4c03046

Cameron B. Berlin, Emily Sidlow, Chris Zheng, Marisa C. Kozlowski

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引用次数: 0

摘要

三氟甲基酮（tfmk）很容易在溶液中形成稳定的水合物和半酮，使它们能够作为氢键供体与生物分子相互作用。这种相互作用是由水合平衡和给定化合物的固有氢键强度共同决定的。用比色传感器紫外-可见滴定法测定了芳基、杂环和烷基tfmk的供氢键能力。数值还根据溶液中水合物的百分比进行了调整，以深入了解水合物的给氢键能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Quantification of the H-Bond-Donating Ability of Trifluoromethyl Ketone Hydrates Using a Colorimetric Sensor

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Quantification of the H-Bond-Donating Ability of Trifluoromethyl Ketone Hydrates Using a Colorimetric Sensor

Trifluoromethyl ketones (TFMKs) readily form stable hydrates and hemiketals in solution, allowing them to interact with biomolecules as hydrogen-bond donors. This interaction is governed by both the hydration equilibrium and the intrinsic hydrogen-bonding strength for a given compound. The hydrogen-bond-donating abilities for aryl, heterocyclic, and alkyl TFMKs were experimentally determined by using UV–vis titrations with a colorimetric sensor. Values were also adjusted based on the percent hydrate present in solution to provide insight into the hydrogen-bond-donating ability of the hydrate species.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.