{"title":"牙龈卟啉单胞菌和星座链球菌所致牙源性脑脓肿1例报告并复习。","authors":"Siyu Sun, Rui He, Shan Chen, Jing Ren, Xinrong Ma, Junying Yang","doi":"10.1080/20002297.2025.2485197","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Odontogenic brain abscess is a rare, but potentially fatal, central nervous system infection, with insidious onset and unclear etiology.</p><p><strong>Methods: </strong>This case reports a 70-year-old male patient who developed an odontogenic brain abscess secondary to periodontal infection and underwent neurological surgery. Extract pus during surgery for the metagenomic next-generation sequencing (mNGS).</p><p><strong>Results: </strong>The mNGS of pus samples obtained from brain abscess aspiration identified the periodontal pathogens <i>Porphyromonas gingivalis</i> and <i>Streptococcus constellatus</i>. Consequently, he was referred to the department of stomatology for further examination and treatment.</p><p><strong>Conclusions: </strong>Our study found that major periodontal pathogens including <i>P. gingivalis</i> and <i>S. constellatus</i> were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"17 1","pages":"2485197"},"PeriodicalIF":3.7000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001842/pdf/","citationCount":"0","resultStr":"{\"title\":\"Odontogenic brain abscess caused by <i>Porphyromonas gingivalis</i> and <i>Streptococcus constellatus</i>: a case report and review article.\",\"authors\":\"Siyu Sun, Rui He, Shan Chen, Jing Ren, Xinrong Ma, Junying Yang\",\"doi\":\"10.1080/20002297.2025.2485197\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Odontogenic brain abscess is a rare, but potentially fatal, central nervous system infection, with insidious onset and unclear etiology.</p><p><strong>Methods: </strong>This case reports a 70-year-old male patient who developed an odontogenic brain abscess secondary to periodontal infection and underwent neurological surgery. Extract pus during surgery for the metagenomic next-generation sequencing (mNGS).</p><p><strong>Results: </strong>The mNGS of pus samples obtained from brain abscess aspiration identified the periodontal pathogens <i>Porphyromonas gingivalis</i> and <i>Streptococcus constellatus</i>. Consequently, he was referred to the department of stomatology for further examination and treatment.</p><p><strong>Conclusions: </strong>Our study found that major periodontal pathogens including <i>P. gingivalis</i> and <i>S. constellatus</i> were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.</p>\",\"PeriodicalId\":16598,\"journal\":{\"name\":\"Journal of Oral Microbiology\",\"volume\":\"17 1\",\"pages\":\"2485197\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001842/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/20002297.2025.2485197\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20002297.2025.2485197","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Odontogenic brain abscess caused by Porphyromonas gingivalis and Streptococcus constellatus: a case report and review article.
Background: Odontogenic brain abscess is a rare, but potentially fatal, central nervous system infection, with insidious onset and unclear etiology.
Methods: This case reports a 70-year-old male patient who developed an odontogenic brain abscess secondary to periodontal infection and underwent neurological surgery. Extract pus during surgery for the metagenomic next-generation sequencing (mNGS).
Results: The mNGS of pus samples obtained from brain abscess aspiration identified the periodontal pathogens Porphyromonas gingivalis and Streptococcus constellatus. Consequently, he was referred to the department of stomatology for further examination and treatment.
Conclusions: Our study found that major periodontal pathogens including P. gingivalis and S. constellatus were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.
期刊介绍：
As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies.
Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics.
Article types: original articles, notes, review articles, mini-reviews and commentaries
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