磷酸甘油酸激酶1作为神经系统疾病的治疗靶点。

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-04-14 DOI:10.1016/j.molmed.2025.03.008

Harriet McHale-Owen, Kiterie M E Faller, Helena Chaytow, Thomas H Gillingwater

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引用次数: 0

摘要

磷酸甘油酸激酶1 （PGK1）是一种高度保守的酶，在糖酵解过程中催化初始atp生成步骤。通过增加PGK1活性来改善细胞能量产生可能有益于多种细胞代谢失调的神经系统疾病，包括帕金森病（PD）和运动神经元疾病（MND）。本综述研究了最近的证据，表明增加PGK1活性可能对多种神经系统疾病有益，并讨论了围绕以PGK1为重点的治疗方法发展的当前挑战。PGK1具有相当大的治疗潜力，但需要新的PGK1激活剂来最大化患者的益处。

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Phosphoglycerate kinase 1 as a therapeutic target in neurological disease.

Phosphoglycerate kinase 1 (PGK1) is a highly conserved enzyme that catalyzes the initial ATP-producing step in glycolysis. Improving cellular energy production by increasing PGK1 activity may be beneficial in multiple neurological conditions where cell metabolism is dysregulated, including Parkinson's disease (PD) and motor neuron disease (MND). This review examines recent evidence that suggests increasing PGK1 activity may be beneficial in multiple neurological conditions and discusses the current challenges surrounding the development of PGK1-focused therapies. PGK1 has considerable therapeutic potential, but novel PGK1 activators are needed to maximize the benefit for patients.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.