{"title":"胶原蛋白补充剂对皮肤衰老的影响：随机对照试验的系统回顾和荟萃分析。","authors":"Seung-Kwon Myung, Yunseo Park","doi":"10.1016/j.amjmed.2025.04.034","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.</p><p><strong>Methods: </strong>PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.</p><p><strong>Results: </strong>A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.</p><p><strong>Conclusions: </strong>There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.\",\"authors\":\"Seung-Kwon Myung, Yunseo Park\",\"doi\":\"10.1016/j.amjmed.2025.04.034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.</p><p><strong>Methods: </strong>PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.</p><p><strong>Results: </strong>A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.</p><p><strong>Conclusions: </strong>There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.</p>\",\"PeriodicalId\":50807,\"journal\":{\"name\":\"American Journal of Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.amjmed.2025.04.034\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.amjmed.2025.04.034","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Background: Collagen supplements are promoted to help aging skin. However, no meta-analysis of randomized controlled trials (RCTs) has examined their effects by funding source and study quality, which may influence outcomes.
Methods: PubMed, Embase, and Cochrane Library were searched from inception to June 14, 2024.
Results: A total of 23 RCTs with 1474 participants were analyzed. In a meta-analysis of all 23 RCTs, collagen supplements significantly improved skin hydration, elasticity, and wrinkles. However, in the subgroup meta-analysis by funding source, studies not receiving funding from pharmaceutical companies revealed no effect of collagen supplements for improving skin hydration, elasticity, and wrinkles, while those receiving funding from pharmaceutical companies did show significant effects. Similarly, high-quality studies revealed no significant effect in all categories, while low-quality studies revealed a significant improvement in elasticity.
Conclusions: There is currently no clinical evidence to support the use of collagen supplements to prevent or treat skin aging.
期刊介绍：
The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
