{"title":"经皮神经电刺激改善老年人认知功能障碍的有效性：一项系统回顾和荟萃分析。","authors":"Nga Huen Chan, Shamay S M Ng","doi":"10.3389/fneur.2025.1556506","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Transcutaneous electrical nerve stimulation (TENS), which involves the application of electrical stimulation to peripheral nerves, is used to improve or maintain cognitive function. Although many studies have examined the effect of TENS on cognition over the past 20 years, a comprehensive review and meta-analysis on this topic is lacking. This study aimed to evaluate the efficacy of TENS in improving cognitive function in older adults with cognitive impairment.</p><p><strong>Methods: </strong>A systematic search was performed in six electronic databases (CINAHL, Cochrane Library, Embase, Medline, PubMed, and Web of Science) to identify relevant studies published until May 2024. Moreover, the registered clinical trials, forward citation searches, and reference lists of identified publications were reviewed to identify additional relevant studies. Randomised controlled trials investigating the effect of TENS on cognitive function in older adults with cognitive impairment were included.</p><p><strong>Results: </strong>Seven studies including 247 older adults with cognitive impairment were included. The findings revealed a trend towards positive effects of TENS on face recognition memory [mean difference (MD) = 1.19, 95% confidence interval (CI) = -0.13 to 2.52] and verbal fluency [standardised MD (SMD) = 0.29, 95% CI = -0.01 to 0.59] when compared with placebo stimulation (control condition). TENS demonstrated a significant positive delayed effect on visual memory (SMD = 0.55, 95% CI = 0.11 to 0.98). Subgroup analysis indicated that TENS applied on the concha was more effective than that applied on the spinal column and earlobe in improving verbal memory in the delayed condition.</p><p><strong>Conclusion: </strong>A positive trend of immediate effect and a significant long-term effect on some cognitive domains were found after applying TENS in in older adults with cognitive impairment. Future studies with robust experimental designs and adequate sample sizes are warranted to investigate the efficacy of TENS in improving cognitive function.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42023408611, PROSPERO: CRD42023408611.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1556506"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056508/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of transcutaneous electrical nerve stimulation in improving cognitive function in older adults with cognitive impairment: a systematic review and meta-analysis.\",\"authors\":\"Nga Huen Chan, Shamay S M Ng\",\"doi\":\"10.3389/fneur.2025.1556506\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Transcutaneous electrical nerve stimulation (TENS), which involves the application of electrical stimulation to peripheral nerves, is used to improve or maintain cognitive function. Although many studies have examined the effect of TENS on cognition over the past 20 years, a comprehensive review and meta-analysis on this topic is lacking. This study aimed to evaluate the efficacy of TENS in improving cognitive function in older adults with cognitive impairment.</p><p><strong>Methods: </strong>A systematic search was performed in six electronic databases (CINAHL, Cochrane Library, Embase, Medline, PubMed, and Web of Science) to identify relevant studies published until May 2024. Moreover, the registered clinical trials, forward citation searches, and reference lists of identified publications were reviewed to identify additional relevant studies. Randomised controlled trials investigating the effect of TENS on cognitive function in older adults with cognitive impairment were included.</p><p><strong>Results: </strong>Seven studies including 247 older adults with cognitive impairment were included. The findings revealed a trend towards positive effects of TENS on face recognition memory [mean difference (MD) = 1.19, 95% confidence interval (CI) = -0.13 to 2.52] and verbal fluency [standardised MD (SMD) = 0.29, 95% CI = -0.01 to 0.59] when compared with placebo stimulation (control condition). TENS demonstrated a significant positive delayed effect on visual memory (SMD = 0.55, 95% CI = 0.11 to 0.98). Subgroup analysis indicated that TENS applied on the concha was more effective than that applied on the spinal column and earlobe in improving verbal memory in the delayed condition.</p><p><strong>Conclusion: </strong>A positive trend of immediate effect and a significant long-term effect on some cognitive domains were found after applying TENS in in older adults with cognitive impairment. Future studies with robust experimental designs and adequate sample sizes are warranted to investigate the efficacy of TENS in improving cognitive function.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42023408611, PROSPERO: CRD42023408611.</p>\",\"PeriodicalId\":12575,\"journal\":{\"name\":\"Frontiers in Neurology\",\"volume\":\"16 \",\"pages\":\"1556506\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056508/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fneur.2025.1556506\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fneur.2025.1556506","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：经皮神经电刺激（TENS）是一种对周围神经进行电刺激的方法，用于改善或维持认知功能。虽然在过去的20 年里，许多研究已经检查了TENS对认知的影响，但缺乏对这一主题的全面回顾和荟萃分析。本研究旨在评价TENS对老年认知功能障碍患者认知功能的改善效果。方法：系统检索6个电子数据库（CINAHL、Cochrane Library、Embase、Medline、PubMed和Web of Science），确定2024年5月前发表的相关研究。此外，我们还回顾了已注册的临床试验、转发引文检索和已确定出版物的参考文献列表，以确定其他相关研究。纳入了调查TENS对认知障碍老年人认知功能影响的随机对照试验。结果：纳入7项研究，包括247名老年认知障碍患者。研究结果显示，与安慰剂刺激（对照组）相比，TENS对面部识别记忆[平均差值（MD） = 1.19,95%可信区间（CI） = -0.13至2.52]和语言流畅性[标准化MD （SMD） = 0.29,95% CI = -0.01至0.59]有积极影响的趋势。TENS对视觉记忆表现出显著的正延迟效应（SMD = 0.55,95% CI = 0.11 ~ 0.98）。亚组分析表明，在延迟条件下，应用于耳甲的TENS比应用于脊柱和耳垂的TENS更有效地改善言语记忆。结论：对老年认知功能障碍患者应用TENS治疗后，在部分认知领域有积极的即时效果和显著的远期效果。未来的研究需要有可靠的实验设计和足够的样本量来研究TENS在改善认知功能方面的功效。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD42023408611, PROSPERO: CRD42023408611。
Effectiveness of transcutaneous electrical nerve stimulation in improving cognitive function in older adults with cognitive impairment: a systematic review and meta-analysis.
Background: Transcutaneous electrical nerve stimulation (TENS), which involves the application of electrical stimulation to peripheral nerves, is used to improve or maintain cognitive function. Although many studies have examined the effect of TENS on cognition over the past 20 years, a comprehensive review and meta-analysis on this topic is lacking. This study aimed to evaluate the efficacy of TENS in improving cognitive function in older adults with cognitive impairment.
Methods: A systematic search was performed in six electronic databases (CINAHL, Cochrane Library, Embase, Medline, PubMed, and Web of Science) to identify relevant studies published until May 2024. Moreover, the registered clinical trials, forward citation searches, and reference lists of identified publications were reviewed to identify additional relevant studies. Randomised controlled trials investigating the effect of TENS on cognitive function in older adults with cognitive impairment were included.
Results: Seven studies including 247 older adults with cognitive impairment were included. The findings revealed a trend towards positive effects of TENS on face recognition memory [mean difference (MD) = 1.19, 95% confidence interval (CI) = -0.13 to 2.52] and verbal fluency [standardised MD (SMD) = 0.29, 95% CI = -0.01 to 0.59] when compared with placebo stimulation (control condition). TENS demonstrated a significant positive delayed effect on visual memory (SMD = 0.55, 95% CI = 0.11 to 0.98). Subgroup analysis indicated that TENS applied on the concha was more effective than that applied on the spinal column and earlobe in improving verbal memory in the delayed condition.
Conclusion: A positive trend of immediate effect and a significant long-term effect on some cognitive domains were found after applying TENS in in older adults with cognitive impairment. Future studies with robust experimental designs and adequate sample sizes are warranted to investigate the efficacy of TENS in improving cognitive function.
期刊介绍：
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