含有EPA和DHA的海洋微生物衍生油对改善甘油三酯和促进血液循环的评价。

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Tae Yeon Yin, Jung-Rae Rho, Yeong Du Yoo, Eun Ju Jeong, Jaeyeon Park, Eun Young Yoon
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引用次数: 0

摘要

心血管疾病(cvd)在全球范围内面临着重大的健康挑战,甘油三酯水平失调和内皮功能受损是其发病机制的关键因素。在这项研究中,我们探索了富含二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的海洋微生物衍生油在解决这些与心血管疾病相关的生理现象方面的潜力。在海洋资源中寻找具有生理活性的化合物与生态因素交织在一起,突出了人类健康与环境之间的相互联系。海洋微生物,特别是原生氧化核糖,是生物活性化合物的丰富来源,包括EPA,以其降脂作用和血管益处而闻名。此外,海洋生物多样性提供了丰富的化合物库,具有潜在的健康促进特性。在这项研究中,我们评估了含有EPA和dha的油在改善甘油三酯水平和促进血液循环方面的功效。脂蛋白脂肪酶(LPL)和一氧化氮(NO)在其作用机制中起关键作用,LPL促进中性脂肪代谢,NO调节血管张力和功能。这项研究为越来越多的证据支持使用海洋衍生化合物预防和管理心血管疾病做出了贡献,强调了海洋生态系统通过可持续地利用海洋生物多样性的生物活性潜力对人类健康的生态重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Marine Microorganism-Derived Oils Containing EPA and DHA for Triglyceride Improvement and Blood Circulation Enhancement.

Cardiovascular diseases (CVDs) present significant health challenges globally, with dysregulated triglyceride levels and impaired endothelial function being key contributors to their pathogenesis. In this study, we explore the potential of marine Microorganism-derived oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in addressing these physiological phenomena associated with CVDs. Exploring marine resources for physiologically active compounds intertwines with ecological considerations, highlighting the interconnectedness between human health and the environment. Marine microorganisms, particularly protist Oxyrrhis, are abundant sources of bioactive compounds, including EPA, known for their lipid-lowering effects and vascular benefits. Additionally, marine biodiversity offers a rich reservoir of compounds with potential health-promoting properties. In this study, we evaluated the efficacy of EPA- and DHA-containing oils in improving triglyceride levels and enhancing blood circulation. Lipoprotein lipase (LPL) and nitric oxide (NO) were identified as pivotal players in the mechanism of action, with LPL facilitating neutral fat metabolism and NO regulating vascular tone and function. This study contributes to the growing evidence supporting the use of marine-derived compounds in preventing and managing CVD, emphasizing the ecological importance of marine ecosystems to human health by leveraging the bioactive potential of marine biodiversity sustainably.

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来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
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