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引用次数: 0
摘要
背景：在杜氏肌营养不良症（DMD）的临床进展过程中，超声（USG）等成像方式可用于评估和监测肌肉骨骼系统。目的：本研究旨在测量杜氏肌营养不良症儿童的被动肌肉僵硬度，并将这些测量值与健康儿童的测量值进行比较。方法：对DMD患者进行临床评价（年龄、临床功能评分、定时Gover评分）、血清肌酸激酶水平、b超、实时组织弹性成像。结果：本研究共纳入64名男童。DMD患者腓肠肌内侧、外侧应变比明显大于对照组(内侧；（1.66±1.23）vs(0.81±0.16),P < 0.001；（1.49±0.52 vs 0.85±0.16,P < 0.001）。结论：杜氏肌营养不良患者腓肠肌内侧和外侧的应变比大于对照组，超声弹性成像可能有助于诊断和随访。
Assessment of Muscular Stiffness in Children with Duchenne Muscular Dystrophy using Real-Time Elastography.
Background: Imaging modalities, such as ultrasonography (USG), can be used to evaluate and monitor the musculoskeletal system during the clinical progression of Duchenne muscular dystrophy (DMD).
Aim: This study aimed to measure passive muscle stiffness in children with Duchenne muscular dystrophy and to compare these measurements with those of healthy children.
Methods: Patients with DMD were evaluated clinically (age, clinical functional score, timed Gover score), serum creatine kinase level, B-mode ultrasonography, and real-time tissue elastography imaging.
Results: A total of 64 boys were included in this study. The medial and lateral gastrocnemius muscle strain ratio in patients with DMD was significantly bigger than that in the control group (medial; 1.66 ± 1.23 vs 0.81 ± 0.16, P < 0.001, lateral; 1.49 ± 0.52 vs 0.85 ± 0.16, P < 0.001).
Conclusion: The strain ratios of the medial and lateral gastrocnemius muscles were greater in patients with Duchenne muscular dystrophy than in the controls, indicating that ultrasound elastography may be beneficial for diagnosis and follow-up.
期刊介绍：
The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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