唑类同型二聚体作为有前景的抗真菌药物：合成、生物活性评价和分子模拟。

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2025-04-30 DOI:10.2174/0109298673351661241219053546

Sergey N. Lavrenov, Alexander Yu. Simonov, Alexey A. Panov, Svetlana E. Solovieva, Alexey B. Mantsyzov, Andrei V. Churakov, Alexey S. Trenin, Igor B. Levshin

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引用次数: 0

摘要

简介：以2-（2,4-二氟苯基）-2,3-环氧-1- （1h -1,2,4-三唑-1-基）丙烷为原料，与多种二胺直接反应，一步合成了一系列具有抗真菌活性的三唑类化合物。方法：对所得化合物进行抑菌活性分析。分子模型用于预测结合模式。结果：该先导物对白色念珠菌的抑制作用是氟康唑的4倍，且活性谱更宽，可抑制黑曲霉的生长。结论：本研究结果可为开发新型抗真菌药物提供参考。

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Azole Homodimers as Promising Antifungal Agents: Synthesis, Biological Activity Evaluation and Molecular Modeling.

Introduction: A new series of triazoles with antifungal activity have been synthesized in a one-step fashion by direct reaction of 2-(2,4-difluorophenyl)-2,3-epoxy-1-(1H-1,2,4-triazol-1-yl)propane with various diamines.

Method: Obtained compounds were profiled for biological activity against pathogenic strains of fungi C. albicans and A. niger. Molecular modeling was used to predict binding modes.

Result: The lead compound was 4 times more active against C. albicans than fluconazole and demonstrated a wider spectrum of activity, inhibiting the growth of A. niger.

Conclusion: The results presented herein can contribute to the development of novel antifungal therapeutic agents.

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.