基于多模态人工智能和免疫学的神经心理胃肠道疾病临床诊疗系统。

IF 2.2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li, Yi Qin
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引用次数: 0

摘要

目的:预测和辅助结直肠癌的治疗。背景:精准医疗系统可以为大肠癌诊疗提供策略优化,满足临床定价机构的需求。目的:设计基于神经免疫基因调控的人工智能多模式胃肠道疾病临床信息系统。方法:该系统包括利用细胞基因表达水平预测癌症患者5年生存率,以及在体细胞检测中建立基于免疫细胞状态和生活习惯的疾病发病率预测模型。利用单细胞测序技术阐明了生存预测系统中特征选择的生物学机制,并利用分子模拟技术对这一机制进行了深入分析。以NCAM1和CADM1基因为基础,进行生物激活通路分析,探讨其协同免疫基因组调控胃肠道肿瘤增殖的生物学机制。结果:各模型的准确率均大于0.70。实验可信度高。结论:研究团队对AI算法的生物学特性进行了详细分析,并与临床专家达成共识。赤峰肿瘤医院伦理批准号为202401,已被世界卫生组织上报。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology.

Objective: To predict and assist in the treatment of colorectal cancer.

Background: Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions.

Aim: To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation.

Method: The system includes the use of cell gene expression levels to predict the 5-year survival rate of cancer patients, and the development of disease incidence rate prediction models based on immune cell status and living habits in somatic cell testing. The biological mechanism of feature selection in survival prediction systems was elucidated using single-cell sequencing technology, and this mechanism was analyzed in depth using molecular simulation techniques. Based on NCAM1 and CADM1 genes, biological activation pathway analysis was conducted to explore the biological mechanism of their synergistic immune genome regulation of gastrointestinal tumor proliferation.

Result: The accuracy of each model is higher than 0.70. The experimental credibility is high.

Conclusion: The research team conducted a detailed analysis of the biological characteristics of AI algorithms and reached a consensus with clinical experts. The ethical approval number of Chifeng Cancer Hospital is 202401, which has been reported by the World Health Organization.

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来源期刊
Current pharmaceutical biotechnology
Current pharmaceutical biotechnology 医学-生化与分子生物学
CiteScore
5.60
自引率
3.60%
发文量
203
审稿时长
6 months
期刊介绍: Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include: DNA/protein engineering and processing Synthetic biotechnology Omics (genomics, proteomics, metabolomics and systems biology) Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes) Drug delivery and targeting Nanobiotechnology Molecular pharmaceutics and molecular pharmacology Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes) Pharmacokinetics and pharmacodynamics Applied Microbiology Bioinformatics (computational biopharmaceutics and modeling) Environmental biotechnology Regenerative medicine (stem cells, tissue engineering and biomaterials) Translational immunology (cell therapies, antibody engineering, xenotransplantation) Industrial bioprocesses for drug production and development Biosafety Biotech ethics Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
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