Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li, Yi Qin
{"title":"基于多模态人工智能和免疫学的神经心理胃肠道疾病临床诊疗系统。","authors":"Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li, Yi Qin","doi":"10.2174/0113892010359130250413024112","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To predict and assist in the treatment of colorectal cancer.</p><p><strong>Background: </strong>Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions.</p><p><strong>Aim: </strong>To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation.</p><p><strong>Method: </strong>The system includes the use of cell gene expression levels to predict the 5-year survival rate of cancer patients, and the development of disease incidence rate prediction models based on immune cell status and living habits in somatic cell testing. The biological mechanism of feature selection in survival prediction systems was elucidated using single-cell sequencing technology, and this mechanism was analyzed in depth using molecular simulation techniques. Based on NCAM1 and CADM1 genes, biological activation pathway analysis was conducted to explore the biological mechanism of their synergistic immune genome regulation of gastrointestinal tumor proliferation.</p><p><strong>Result: </strong>The accuracy of each model is higher than 0.70. The experimental credibility is high.</p><p><strong>Conclusion: </strong>The research team conducted a detailed analysis of the biological characteristics of AI algorithms and reached a consensus with clinical experts. The ethical approval number of Chifeng Cancer Hospital is 202401, which has been reported by the World Health Organization.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology.\",\"authors\":\"Liangyu Li, Jun Jiang, Lizhong Guo, Javier Santos, Ana María González, Siyi Li, Yi Qin\",\"doi\":\"10.2174/0113892010359130250413024112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To predict and assist in the treatment of colorectal cancer.</p><p><strong>Background: </strong>Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions.</p><p><strong>Aim: </strong>To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation.</p><p><strong>Method: </strong>The system includes the use of cell gene expression levels to predict the 5-year survival rate of cancer patients, and the development of disease incidence rate prediction models based on immune cell status and living habits in somatic cell testing. The biological mechanism of feature selection in survival prediction systems was elucidated using single-cell sequencing technology, and this mechanism was analyzed in depth using molecular simulation techniques. Based on NCAM1 and CADM1 genes, biological activation pathway analysis was conducted to explore the biological mechanism of their synergistic immune genome regulation of gastrointestinal tumor proliferation.</p><p><strong>Result: </strong>The accuracy of each model is higher than 0.70. The experimental credibility is high.</p><p><strong>Conclusion: </strong>The research team conducted a detailed analysis of the biological characteristics of AI algorithms and reached a consensus with clinical experts. The ethical approval number of Chifeng Cancer Hospital is 202401, which has been reported by the World Health Organization.</p>\",\"PeriodicalId\":10881,\"journal\":{\"name\":\"Current pharmaceutical biotechnology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-04-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current pharmaceutical biotechnology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0113892010359130250413024112\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current pharmaceutical biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113892010359130250413024112","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Clinical Diagnosis and Treatment System for Neurological Psychological Gastrointestinal Diseases Based on Multimodal Artificial Intelligence and Immunology.
Objective: To predict and assist in the treatment of colorectal cancer.
Background: Precision medicine systems can provide strategy optimization for the diagnosis and treatment of colorectal cancer to meet the needs of clinical pricing institutions.
Aim: To design an artificial intelligence multimodal gastrointestinal disease clinical information system based on neuroimmune gene regulation.
Method: The system includes the use of cell gene expression levels to predict the 5-year survival rate of cancer patients, and the development of disease incidence rate prediction models based on immune cell status and living habits in somatic cell testing. The biological mechanism of feature selection in survival prediction systems was elucidated using single-cell sequencing technology, and this mechanism was analyzed in depth using molecular simulation techniques. Based on NCAM1 and CADM1 genes, biological activation pathway analysis was conducted to explore the biological mechanism of their synergistic immune genome regulation of gastrointestinal tumor proliferation.
Result: The accuracy of each model is higher than 0.70. The experimental credibility is high.
Conclusion: The research team conducted a detailed analysis of the biological characteristics of AI algorithms and reached a consensus with clinical experts. The ethical approval number of Chifeng Cancer Hospital is 202401, which has been reported by the World Health Organization.
期刊介绍:
Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:
DNA/protein engineering and processing
Synthetic biotechnology
Omics (genomics, proteomics, metabolomics and systems biology)
Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
Drug delivery and targeting
Nanobiotechnology
Molecular pharmaceutics and molecular pharmacology
Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
Pharmacokinetics and pharmacodynamics
Applied Microbiology
Bioinformatics (computational biopharmaceutics and modeling)
Environmental biotechnology
Regenerative medicine (stem cells, tissue engineering and biomaterials)
Translational immunology (cell therapies, antibody engineering, xenotransplantation)
Industrial bioprocesses for drug production and development
Biosafety
Biotech ethics
Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.
Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.