遗传性脂肪营养不良综合征的诊断和治疗及其对动脉粥样硬化的影响。

IF 5.7 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Josivan Gomes Lima, Izabely Galvao Menezes Dantas, Lucas Nobrega Lima
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引用次数: 0

摘要

综述目的:本文探讨了与遗传性脂肪营养不良综合征(ld)相关的诊断和管理挑战及其对动脉粥样硬化和心血管健康的影响。最近发现:遗传性脂肪营养不良,如家族性部分性脂肪营养不良(FPLD)和先天性全身性脂肪营养不良(CGL),其特征是脂肪分布异常和显著的代谢并发症。FPLD患者经常被误诊为2型糖尿病;CGL患者可能早死于非心血管原因,给人的印象是心血管疾病并不常见。实际上,这些综合征与心血管风险增加和早发性动脉粥样硬化有关。心血管疾病在LD患者中很常见;高度怀疑对于早期诊断和有效管理遗传性ld以减轻相关心血管风险至关重要。持续研究创新疗法和更好地了解潜在机制对于改善患者预后和减轻这些综合征的医疗负担至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnosis and Management of Genetic Lipodystrophy Syndromes and its Implications for Atherosclerosis.

Purpose of review: This paper explores the diagnostic and management challenges associated with genetic lipodystrophy syndromes (LDs) and their implications for atherosclerosis and cardiovascular health.

Recent findings: Genetic LDs, such as familial partial lipodystrophy (FPLD) and congenital generalized lipodystrophy (CGL), are characterized by abnormal fat distribution and significant metabolic complications. FPLD patients are often misdiagnosed as having type 2 diabetes; CGL patients may die early from noncardiovascular causes, giving the impression that cardiovascular disease is not frequent. Actually, these syndromes are associated with increased cardiovascular risks and early-onset atherosclerosis. Cardiovascular disease is common in LD patients; a high level of suspicion is essential for early diagnosis and effective management of genetic LDs to mitigate associated cardiovascular risks. Continued research into innovative therapies and a better understanding of the underlying mechanisms are crucial for improving patient outcomes and alleviating the healthcare burden of these syndromes.

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来源期刊
CiteScore
9.00
自引率
3.40%
发文量
87
审稿时长
6-12 weeks
期刊介绍: The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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