Daisy Duan, Luu V Pham, Jonathan C Jun, Ruth-Alma Turkson-Ocran, Scott J Pilla, Jeanne M Clark, Nisa M Maruthur
{"title":"限时进食对活动图衍生睡眠参数的影响:随机等热量进食研究的事后分析。","authors":"Daisy Duan, Luu V Pham, Jonathan C Jun, Ruth-Alma Turkson-Ocran, Scott J Pilla, Jeanne M Clark, Nisa M Maruthur","doi":"10.1093/sleep/zsaf089","DOIUrl":null,"url":null,"abstract":"<p><strong>Study objectives: </strong>Time-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored.</p><p><strong>Methods: </strong>This was a post hoc analysis of a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes/diabetes, randomized to TRE (08:00 am-06:00 pm) or usual eating pattern (UEP; 08:00 am-12:00 am) for 12 weeks. We objectively determined sleep-wake patterns from 7-day wrist actigraphy data obtained at baseline and week 12. From this data, we derived total sleep time (TST) and sleep midpoint over a 24-hour period, sleep onset/offset, and sleep continuity measures. We used paired t-tests or Wilcoxon signed rank tests to compare data between baseline and week 12 within intervention arms and Mann-Whitney U tests or Wilcoxon signed rank tests to compare changes between intervention arms.</p><p><strong>Results: </strong>38 participants (20 UEP; 18 TRE; 93% of those randomized in the parent trial) with adequate actigraphy data (mean age 59.6 ± 7.3 years, 92% female, 92% Black, mean BMI 36.3 ± 4.7 kg/m2) were analyzed. Compared to UEP, TRE increased TST by 55 minutes (p = .03). TRE shifted sleep midpoint to 44 minutes earlier, from 03:24 am to 02:40 am (p = .01), while UEP maintained the same sleep midpoint at 03:15 am. Sleep onset shifted from a median of 12:22 am to 11:52 pm in TRE (p = .03) while it remained stable in UEP (p = .97). There were no differences in sleep offset and sleep continuity within and between intervention arms.</p><p><strong>Conclusions: </strong>TRE increased sleep time and caused earlier sleep onset compared to UEP, revealing how the timing of eating may affect sleep timing and duration.</p><p><strong>Clinical trial: </strong>The Time Restricted Intake of Meals Study (TRIM). URL: https://clinicaltrials.gov/study/NCT03527368?tab=history&a=4.</p><p><strong>Registration: </strong>NCT03527368.</p>","PeriodicalId":22018,"journal":{"name":"Sleep","volume":" ","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study.\",\"authors\":\"Daisy Duan, Luu V Pham, Jonathan C Jun, Ruth-Alma Turkson-Ocran, Scott J Pilla, Jeanne M Clark, Nisa M Maruthur\",\"doi\":\"10.1093/sleep/zsaf089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Study objectives: </strong>Time-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored.</p><p><strong>Methods: </strong>This was a post hoc analysis of a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes/diabetes, randomized to TRE (08:00 am-06:00 pm) or usual eating pattern (UEP; 08:00 am-12:00 am) for 12 weeks. We objectively determined sleep-wake patterns from 7-day wrist actigraphy data obtained at baseline and week 12. From this data, we derived total sleep time (TST) and sleep midpoint over a 24-hour period, sleep onset/offset, and sleep continuity measures. We used paired t-tests or Wilcoxon signed rank tests to compare data between baseline and week 12 within intervention arms and Mann-Whitney U tests or Wilcoxon signed rank tests to compare changes between intervention arms.</p><p><strong>Results: </strong>38 participants (20 UEP; 18 TRE; 93% of those randomized in the parent trial) with adequate actigraphy data (mean age 59.6 ± 7.3 years, 92% female, 92% Black, mean BMI 36.3 ± 4.7 kg/m2) were analyzed. Compared to UEP, TRE increased TST by 55 minutes (p = .03). TRE shifted sleep midpoint to 44 minutes earlier, from 03:24 am to 02:40 am (p = .01), while UEP maintained the same sleep midpoint at 03:15 am. Sleep onset shifted from a median of 12:22 am to 11:52 pm in TRE (p = .03) while it remained stable in UEP (p = .97). 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Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study.
Study objectives: Time-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored.
Methods: This was a post hoc analysis of a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes/diabetes, randomized to TRE (08:00 am-06:00 pm) or usual eating pattern (UEP; 08:00 am-12:00 am) for 12 weeks. We objectively determined sleep-wake patterns from 7-day wrist actigraphy data obtained at baseline and week 12. From this data, we derived total sleep time (TST) and sleep midpoint over a 24-hour period, sleep onset/offset, and sleep continuity measures. We used paired t-tests or Wilcoxon signed rank tests to compare data between baseline and week 12 within intervention arms and Mann-Whitney U tests or Wilcoxon signed rank tests to compare changes between intervention arms.
Results: 38 participants (20 UEP; 18 TRE; 93% of those randomized in the parent trial) with adequate actigraphy data (mean age 59.6 ± 7.3 years, 92% female, 92% Black, mean BMI 36.3 ± 4.7 kg/m2) were analyzed. Compared to UEP, TRE increased TST by 55 minutes (p = .03). TRE shifted sleep midpoint to 44 minutes earlier, from 03:24 am to 02:40 am (p = .01), while UEP maintained the same sleep midpoint at 03:15 am. Sleep onset shifted from a median of 12:22 am to 11:52 pm in TRE (p = .03) while it remained stable in UEP (p = .97). There were no differences in sleep offset and sleep continuity within and between intervention arms.
Conclusions: TRE increased sleep time and caused earlier sleep onset compared to UEP, revealing how the timing of eating may affect sleep timing and duration.
Clinical trial: The Time Restricted Intake of Meals Study (TRIM). URL: https://clinicaltrials.gov/study/NCT03527368?tab=history&a=4.
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