老年人营养风险指数作为肝硬化患者总生存率的预测指标:一项回顾性队列研究。

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Chun-Yan Sun, Yu-Ning Wang, Hong-Fei Zhan, Yan Sun, Ya-Ping Guan, Yong Lin, Ling-Yan Cai, Xin Zeng
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引用次数: 0

摘要

目的:老年人营养风险指数(GNRI)被广泛用于营养评估。营养状况不良与肝硬化患者的并发症和生存率低有关。我们的目的是研究GNRI在预测肝硬化患者预后方面的价值。方法:本回顾性研究纳入了2013年至2017年来自三个中心的420例肝硬化患者。将患者分为高GNRI组(≥92)和低GNRI组(结果:2年随访期间,58例(13.81%)患者死亡,262例(62.38%)患者出现并发症。与低GNRI组患者相比,高GNRI组患者的死亡率较低(18.73% vs. 5.23%)。结论:较低的GNRI评分与肝硬化患者较高的累积并发症发生率和较差的OS相关。GNRI可以作为评估这些患者营养状况和预后的有用工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Geriatric Nutritional Risk Index as a Predictor of Overall Survival in Cirrhosis: A Retrospective Cohort Study.

Objective: The geriatric nutritional risk index (GNRI) is widely used for nutritional assessment. Poor nutritional status is associated with complications and poor survival in cirrhotic patients. We aimed to investigate the value of the GNRI in predicting outcomes in cirrhotic patients.

Methods: This retrospective study included 420 cirrhotic patients from three centers between 2013 and 2017. Patients were divided into the high GNRI group (≥ 92) and low GNRI group (< 92). Overall survival (OS) in the two groups was evaluated via the Kaplan‒Meier method. Cox proportional hazards model was used to estimate the value of the GNRI in predicting outcomes. Restricted cubic spline model was used to intuitively display the dose‒response associations between the GNRI and OS. A nomogram was constructed to predict OS.

Results: During the 2-year follow-up period, 58 (13.81%) patients died, and 262 (62.38%) patients experienced episodes of complications. Compared with patients in the low GNRI group, those in the high GNRI group had lower mortality rates (18.73% vs. 5.23%, P < 0.001). The GNRI was an independent predictor of OS (hazard ratio [HR] = 0.958, 95% confidence interval [CI] 0.929-0.988, P = 0.007). The GNRI was associated with the cumulative incidence of ascites (HR = 0. 954, 95% CI 0.940-0.969, P < 0.001), spontaneous bacterial peritonitis (HR = 0.928, 95% CI 0.891-0.966, P < 0.001), hepatic encephalopathy (HE; HR = 0.944, 95% CI 0.920-0.968, P < 0.001), and hepatorenal syndrome (HRS) (HR = 0.916, 95% CI 0.861-0.974, P = 0.005). Furthermore, 6 independent factors were included to construct the nomogram for OS prediction, including GNRI, age, total bilirubin, serum sodium, history of HE and HRS. The C statistics of our model were 0.83 (95% CI 0.75-0.90) and 0.80 (95% CI 0.73-0.86) at 1 and 2 years, respectively. Patients whose GNRI score decreased within 3 and 6 months had poorer outcomes (P < 0.001).

Conclusions: The lower GNRI score was associated with the higher cumulative incidence of complications and poorer OS of cirrhotic patients. The GNRI could be a helpful tool for assessing nutritional status and prognosis of these patients.

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来源期刊
Current Medical Science
Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
4.70
自引率
0.00%
发文量
126
期刊介绍: Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.
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