{"title":"防治结核病病理：先进诊断、创新疗法和公共卫生策略综述。","authors":"Satyajit Mohanty, Manmeet Kaur Khanna, Krishnendu Adhikary, Tuhin Mukherjee, Anwesha Sahu, Ivan Kahwa, Pranav Kumar Prabhakar, Mahendra Pratap Swain, Anasuya Sahoo, Manoj Kumar Parida","doi":"10.2174/0113892010355430250330074301","DOIUrl":null,"url":null,"abstract":"<p><p>Tuberculosis (TB) continues to be a major global health challenge, largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs, focusing on those currently in clinical trials. Additionally, innovative approaches like immunotherapy, combination therapy, and adjunct therapy, which include the use of phytochemicals, are examined for their potential to enhance treatment outcomes and tackle drug resistance. These innovative approaches could be the key to the future of the fight against TB. It also highlights how these strategies could accelerate TB treatment. It incorporates public health strategies for preventing TB transmission and ensuring patients adhere to treatments. By addressing these key areas, this work aims to contribute to the global fight against TB and improve the lives of those affected by the disease.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review.\",\"authors\":\"Satyajit Mohanty, Manmeet Kaur Khanna, Krishnendu Adhikary, Tuhin Mukherjee, Anwesha Sahu, Ivan Kahwa, Pranav Kumar Prabhakar, Mahendra Pratap Swain, Anasuya Sahoo, Manoj Kumar Parida\",\"doi\":\"10.2174/0113892010355430250330074301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tuberculosis (TB) continues to be a major global health challenge, largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs, focusing on those currently in clinical trials. Additionally, innovative approaches like immunotherapy, combination therapy, and adjunct therapy, which include the use of phytochemicals, are examined for their potential to enhance treatment outcomes and tackle drug resistance. These innovative approaches could be the key to the future of the fight against TB. It also highlights how these strategies could accelerate TB treatment. It incorporates public health strategies for preventing TB transmission and ensuring patients adhere to treatments. By addressing these key areas, this work aims to contribute to the global fight against TB and improve the lives of those affected by the disease.</p>\",\"PeriodicalId\":10881,\"journal\":{\"name\":\"Current pharmaceutical biotechnology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current pharmaceutical biotechnology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0113892010355430250330074301\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current pharmaceutical biotechnology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113892010355430250330074301","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review.
Tuberculosis (TB) continues to be a major global health challenge, largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs, focusing on those currently in clinical trials. Additionally, innovative approaches like immunotherapy, combination therapy, and adjunct therapy, which include the use of phytochemicals, are examined for their potential to enhance treatment outcomes and tackle drug resistance. These innovative approaches could be the key to the future of the fight against TB. It also highlights how these strategies could accelerate TB treatment. It incorporates public health strategies for preventing TB transmission and ensuring patients adhere to treatments. By addressing these key areas, this work aims to contribute to the global fight against TB and improve the lives of those affected by the disease.
期刊介绍：
Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:
DNA/protein engineering and processing
Synthetic biotechnology
Omics (genomics, proteomics, metabolomics and systems biology)
Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
Drug delivery and targeting
Nanobiotechnology
Molecular pharmaceutics and molecular pharmacology
Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
Pharmacokinetics and pharmacodynamics
Applied Microbiology
Bioinformatics (computational biopharmaceutics and modeling)
Environmental biotechnology
Regenerative medicine (stem cells, tissue engineering and biomaterials)
Translational immunology (cell therapies, antibody engineering, xenotransplantation)
Industrial bioprocesses for drug production and development
Biosafety
Biotech ethics
Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.
Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
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