心肌纤维化在保留射血分数的心力衰竭中的演变作用。

IF 2.8 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Frontiers in Cardiovascular Medicine Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI:10.3389/fcvm.2025.1573346

Muhammad K Malik, Menhel Kinno, Max Liebo, Mingxi D Yu, Mushabbar Syed

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引用次数: 0

摘要

心力衰竭伴射血分数保留（HFpEF）是一种复杂的临床诊断，具有不同的病理生理和临床表现。HFpEF的标志是与左室重构和纤维化相关的舒张功能障碍。心肌间质纤维化（MIF）是胶原沉积的结果，并依赖于心力衰竭的潜在病因。MIF的检测可以通过侵入性组织病理学取样或成像来完成。最近，新的生物标志物被研究作为一种替代工具，不仅可以检测MIF，还可以预测HFpEF患者的预后，这可能会减轻未来对侵入性和昂贵的成像的需求。

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Evolving role of myocardial fibrosis in heart failure with preserved ejection fraction.

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical diagnosis with a heterogeneous pathophysiology and clinical presentation. The hallmark of HFpEF is diastolic dysfunction associated with left ventricular remodeling and fibrosis. Myocardial interstitial fibrosis (MIF) occurs as the result of collagen deposition and is dependent on the underlying etiology of heart failure. Detection of MIF can be done by invasive histopathologic sampling or by imaging. More recently, novel biomarkers have been investigated as an alternative tool for not only the detection of MIF but also for the prognostication of patients with HFpEF which may in turn alleviate the need for invasive and expensive imaging in the future.

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来源期刊

Frontiers in Cardiovascular Medicine Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.80

自引率

11.10%

发文量

3529

审稿时长

14 weeks

期刊介绍： Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers? At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.