[从木香根中发现的两种新的倍半萜类化合物及其farnesoid X受体激动剂活性]。

Q3 Pharmacology, Toxicology and Pharmaceutics

Zhongguo Zhongyao Zazhi Pub Date : 2025-04-01 DOI:10.19540/j.cnki.cjcmm.20250107.201

Qian-Yu Chen, Dan Huang, Hong-Hong Zhan, Fan-Cheng Meng, Guo-Wei Wang, Min Chen

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引用次数: 0

摘要

综合运用多种色谱方法对木香乙酸乙酯提取物的化学成分进行了研究。所有化合物的结构都是通过分析它们的物理化学性质和光谱方法来确定的。分离鉴定了两个新的倍半萜类化合物，命名为auclappsines A和B（1和2）。通过体外高含量筛选，利用谷胱甘酮诱导的L02细胞，研究了1和2对法内甾体X受体（FXR）蛋白表达的影响。结果表明，1具有明显的FXR激活作用，为开发治疗肝胆疾病的药物提供了科学依据。

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[Two new sesquiterpenoids from Aucklandiae Radix and their farnesoid X receptor agonist activity].

Various chromatographic methods were comprehensively applied to study the chemical composition of the ethyl acetate extract from Aucklandiae Radix. The structures of all compounds were identified by analyzing their physicochemical properties and using spectroscopic methods. Two new sesquiterpenoids, named auclappsines A and B(1 and 2) were isolated and identified. Through in vitro high content screening and with the use of a guggulsterone-induced L02 cells, the effects of 1 and 2 on farnesoid X receptor(FXR) protein expression were investigated. The results showed that 1 had a significant FXR activation effect, providing a scientific basis for the development of drugs for the treatment of liver and gallbladder diseases.

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来源期刊

Zhongguo Zhongyao Zazhi Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.50

自引率

0.00%

发文量

581

期刊介绍：