妊娠特异性糖蛋白1在动物模型中促进伤口愈合。

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2025-04-29 DOI:10.1111/eci.70056

Tom Moore, John M Williams, Kathy Barriscale Walsh, Derek Whelan, James Clover

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引用次数: 0

摘要

在小鼠和猪（包括急性糖尿病小鼠模型）的伤口边缘皮内给药重组人PSG1可促进皮肤伤口愈合。在猪身上观察到对伤口再上皮化的高度显著影响，并且PSG1处理人类HaCaT角化细胞细胞系在体外调节伤口愈合相关基因并增强单层细胞的划伤愈合。临床应用PSG1可促进切口和外伤性伤口的闭合，促进烧伤的再上皮化。

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Pregnancy-specific glycoprotein 1 promotes wound closure in animal models.

Recombinant human PSG1 administered intradermally at wound margins enhances skin wound healing in the mouse and pig, including in an acute diabetic mouse model. A highly significant effect on wound re-epithelialisation was observed in the pig, and PSG1 treatment of the human HaCaT keratinocyte cell line regulated wound healing-associated genes and enhanced scratch wound closure in cell monolayers in vitro. Clinical use of PSG1 might enhance closure of incisional and traumatic wounds and enhance re-epithelialisation of burn injuries.

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.