{"title":"墨西哥人群妊娠11-14周鼻骨发育不全对胎儿非整倍体检测的价值","authors":"Cervantes-Ricaud J Alfredo, Oviedo-Cruz Héctor","doi":"10.24875/GMM.M24000960","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The standardized assessment of the hypoplastic nasal bone (NB) by ultrasonography between 11-14 weeks' gestation has value in the detection of fetal aneuploidies. The frequency of hypoplastic NB varies between populations and is unknown in Mexico.</p><p><strong>Objective: </strong>To analyze the performance of hypoplastic NB for the early detection of fetal aneuploidies in a Mexican population.</p><p><strong>Material and methods: </strong>A nested case-control study in a cohort of Mexican pregnant women. The inclusion criteria were live fetus with crown-rump length (CRL) 45-84 mm and the result of perinatal karyotype or phenotype at birth. Ultrasonographic assessment of the NB was standardized. The statistical analyses were univariable, multiple logistic regression, Bayes' theorem and performance.</p><p><strong>Results: </strong>A total of 65 cases and 1187 controls were studied, with maternal age of 1753 years. The frequency of hypoplastic NB was 1.6% (95% CI, 0.9-2.3) in euploid fetuses versus 44.6% (95% CI, 32.5-56.7) with aneuploidies (p < 0.001, X<sup>2</sup>). Sensitivity for trisomy 21 was 58.3% (PPV 52.5%, NPV 98.7%). The probability of the hypoplastic NB was conditioned by aneuploidy (type), CRL, and nuchal translucency. The C-statistic of the Bayesian model was 0.904 (95% CI, 0.842-0.965).</p><p><strong>Conclusions: </strong>A Mexican model of the NB had added value in the early detection of fetal aneuploidies.</p>","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"160 6","pages":"619-626"},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Value of hypoplastic nasal bone at 11-14 weeks' gestation for the detection of fetal aneuploidy in a Mexican population.\",\"authors\":\"Cervantes-Ricaud J Alfredo, Oviedo-Cruz Héctor\",\"doi\":\"10.24875/GMM.M24000960\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The standardized assessment of the hypoplastic nasal bone (NB) by ultrasonography between 11-14 weeks' gestation has value in the detection of fetal aneuploidies. The frequency of hypoplastic NB varies between populations and is unknown in Mexico.</p><p><strong>Objective: </strong>To analyze the performance of hypoplastic NB for the early detection of fetal aneuploidies in a Mexican population.</p><p><strong>Material and methods: </strong>A nested case-control study in a cohort of Mexican pregnant women. The inclusion criteria were live fetus with crown-rump length (CRL) 45-84 mm and the result of perinatal karyotype or phenotype at birth. Ultrasonographic assessment of the NB was standardized. The statistical analyses were univariable, multiple logistic regression, Bayes' theorem and performance.</p><p><strong>Results: </strong>A total of 65 cases and 1187 controls were studied, with maternal age of 1753 years. The frequency of hypoplastic NB was 1.6% (95% CI, 0.9-2.3) in euploid fetuses versus 44.6% (95% CI, 32.5-56.7) with aneuploidies (p < 0.001, X<sup>2</sup>). Sensitivity for trisomy 21 was 58.3% (PPV 52.5%, NPV 98.7%). The probability of the hypoplastic NB was conditioned by aneuploidy (type), CRL, and nuchal translucency. The C-statistic of the Bayesian model was 0.904 (95% CI, 0.842-0.965).</p><p><strong>Conclusions: </strong>A Mexican model of the NB had added value in the early detection of fetal aneuploidies.</p>\",\"PeriodicalId\":12736,\"journal\":{\"name\":\"Gaceta medica de Mexico\",\"volume\":\"160 6\",\"pages\":\"619-626\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gaceta medica de Mexico\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.24875/GMM.M24000960\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gaceta medica de Mexico","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.24875/GMM.M24000960","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Value of hypoplastic nasal bone at 11-14 weeks' gestation for the detection of fetal aneuploidy in a Mexican population.
Background: The standardized assessment of the hypoplastic nasal bone (NB) by ultrasonography between 11-14 weeks' gestation has value in the detection of fetal aneuploidies. The frequency of hypoplastic NB varies between populations and is unknown in Mexico.
Objective: To analyze the performance of hypoplastic NB for the early detection of fetal aneuploidies in a Mexican population.
Material and methods: A nested case-control study in a cohort of Mexican pregnant women. The inclusion criteria were live fetus with crown-rump length (CRL) 45-84 mm and the result of perinatal karyotype or phenotype at birth. Ultrasonographic assessment of the NB was standardized. The statistical analyses were univariable, multiple logistic regression, Bayes' theorem and performance.
Results: A total of 65 cases and 1187 controls were studied, with maternal age of 1753 years. The frequency of hypoplastic NB was 1.6% (95% CI, 0.9-2.3) in euploid fetuses versus 44.6% (95% CI, 32.5-56.7) with aneuploidies (p < 0.001, X2). Sensitivity for trisomy 21 was 58.3% (PPV 52.5%, NPV 98.7%). The probability of the hypoplastic NB was conditioned by aneuploidy (type), CRL, and nuchal translucency. The C-statistic of the Bayesian model was 0.904 (95% CI, 0.842-0.965).
Conclusions: A Mexican model of the NB had added value in the early detection of fetal aneuploidies.
期刊介绍：
Gaceta Médica de México México is the official scientific journal of the Academia Nacional de Medicina de México, A.C. Its goal is to contribute to health professionals by publishing the most relevant progress both in research and clinical practice.
Gaceta Médica de México is a bimonthly peer reviewed journal, published both in paper and online in open access, both in Spanish and English. It has a brilliant editorial board formed by national and international experts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
