Sarah B Lieber, Yvonne M Shea, Deanna Jannat-Khah, John A Carrino, M Carrington Reid, Lisa A Mandl
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We compared self-report functional measures and performance-based measures of physical function between dichotomized SARC-F scores (≥4 vs <4). We used Pearson correlations and linear and logistic regression to evaluate the relationship between the SARC-F as a continuous and dichotomous score with self-report functional measures and performance-based measures of physical function.ResultsOf 47 participants, 16 (34%) had worse SARC-F scores (i.e., ≥4). Participants with SARC-F ≥4 had worse organ damage and functional measures than those with SARC-F <4 (all <i>p</i> < 0.01). SARC-F continuous scores were correlated with hand grip strength, 4-m walk test, and self-report disability (all <i>p</i> < 0.01) and associated with functional status measures, including after adjustment (<i>p</i> < 0.01 to <i>p</i> = 0.046). Dichotomous SARC-F was associated with 4-m walk test (<i>p</i> < 0.01), including in adjusted models.ConclusionAmong women with SLE, SARC-F was significantly associated with multiple functional status measures, suggesting that SARC-F is a promising screening tool for detection of sarcopenia among women with SLE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":"34 6","pages":"626-632"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097523/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of a self-report screening tool for sarcopenia (SARC-F) with functional status outcomes in systemic lupus erythematosus.\",\"authors\":\"Sarah B Lieber, Yvonne M Shea, Deanna Jannat-Khah, John A Carrino, M Carrington Reid, Lisa A Mandl\",\"doi\":\"10.1177/09612033251332054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Background/PurposeSarcopenia, i.e., loss of skeletal muscle mass and strength, is associated with poorer health. Although limited data suggest that sarcopenia is more prevalent among adults with (vs without) systemic lupus erythematosus (SLE), current methods for assessing sarcopenia are cumbersome and not widely available. We assessed associations of a self-report screening tool for sarcopenia (SARC-F) with functional outcomes in adults with SLE.MethodsWe obtained self-report functional measures and performance-based measures of physical function from women ≥18 years of age with SLE. Participants completed the SARC-F, covering strength, assistance walking, rising from a chair, climbing stairs, and falls. We compared self-report functional measures and performance-based measures of physical function between dichotomized SARC-F scores (≥4 vs <4). We used Pearson correlations and linear and logistic regression to evaluate the relationship between the SARC-F as a continuous and dichotomous score with self-report functional measures and performance-based measures of physical function.ResultsOf 47 participants, 16 (34%) had worse SARC-F scores (i.e., ≥4). Participants with SARC-F ≥4 had worse organ damage and functional measures than those with SARC-F <4 (all <i>p</i> < 0.01). SARC-F continuous scores were correlated with hand grip strength, 4-m walk test, and self-report disability (all <i>p</i> < 0.01) and associated with functional status measures, including after adjustment (<i>p</i> < 0.01 to <i>p</i> = 0.046). Dichotomous SARC-F was associated with 4-m walk test (<i>p</i> < 0.01), including in adjusted models.ConclusionAmong women with SLE, SARC-F was significantly associated with multiple functional status measures, suggesting that SARC-F is a promising screening tool for detection of sarcopenia among women with SLE.</p>\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":\"34 6\",\"pages\":\"626-632\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097523/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033251332054\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251332054","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景/目的骨骼肌减少症,即骨骼肌质量和力量的减少,与较差的健康状况有关。虽然有限的数据表明,肌少症在系统性红斑狼疮(SLE)的成年人中更为普遍,但目前评估肌少症的方法繁琐且不广泛应用。我们评估了成人SLE患者肌少症(SARC-F)自我报告筛查工具与功能结局的关系。方法:我们从年龄≥18岁的SLE女性患者中获得自我报告功能测量和基于表现的身体功能测量。参与者完成了SARC-F,包括力量、辅助行走、从椅子上站起来、爬楼梯和跌倒。我们比较了自我报告功能测量和基于表现的身体功能测量在二分类SARC-F评分之间的差异(≥4 vs p < 0.01)。SARC-F连续评分与握力、4米步行测试和自述残疾相关(均p < 0.01),并与功能状态测量相关,包括调整后(p < 0.01至p = 0.046)。二分类SARC-F与4米步行试验相关(p < 0.01),包括调整后的模型。结论在SLE女性患者中,SARC-F与多项功能状态指标显著相关,提示SARC-F是一种有前景的SLE女性肌少症筛查工具。
Association of a self-report screening tool for sarcopenia (SARC-F) with functional status outcomes in systemic lupus erythematosus.
Background/PurposeSarcopenia, i.e., loss of skeletal muscle mass and strength, is associated with poorer health. Although limited data suggest that sarcopenia is more prevalent among adults with (vs without) systemic lupus erythematosus (SLE), current methods for assessing sarcopenia are cumbersome and not widely available. We assessed associations of a self-report screening tool for sarcopenia (SARC-F) with functional outcomes in adults with SLE.MethodsWe obtained self-report functional measures and performance-based measures of physical function from women ≥18 years of age with SLE. Participants completed the SARC-F, covering strength, assistance walking, rising from a chair, climbing stairs, and falls. We compared self-report functional measures and performance-based measures of physical function between dichotomized SARC-F scores (≥4 vs <4). We used Pearson correlations and linear and logistic regression to evaluate the relationship between the SARC-F as a continuous and dichotomous score with self-report functional measures and performance-based measures of physical function.ResultsOf 47 participants, 16 (34%) had worse SARC-F scores (i.e., ≥4). Participants with SARC-F ≥4 had worse organ damage and functional measures than those with SARC-F <4 (all p < 0.01). SARC-F continuous scores were correlated with hand grip strength, 4-m walk test, and self-report disability (all p < 0.01) and associated with functional status measures, including after adjustment (p < 0.01 to p = 0.046). Dichotomous SARC-F was associated with 4-m walk test (p < 0.01), including in adjusted models.ConclusionAmong women with SLE, SARC-F was significantly associated with multiple functional status measures, suggesting that SARC-F is a promising screening tool for detection of sarcopenia among women with SLE.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…