法瑞昔单抗玻璃体内注射引起双侧无菌性肉芽肿性葡萄膜炎。

IF 0.5 Q4 OPHTHALMOLOGY
Christine Hill, Dimitrios C Arhontoulis, Huyen Bui, Sarah M DeVaro, Peter H Tang
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引用次数: 0

摘要

目的:报告一例因法利西单抗治疗引起的严重双侧肉芽肿性葡萄膜炎。方法:对1例病例进行回顾性分析。结果:一名患有糖尿病性黄斑水肿的79岁女性患者在双侧玻璃体内(IVT)注射法昔单抗16天后发生了严重的葡萄膜炎。患者的视觉灵敏度(VA)为手部运动OD和20/400 OS。她拒绝在床边静脉注射抗生素,但同意紧急玻璃体切割手术(PPV)。感染性和自身免疫性病因的实验室检查不显著,PPV的细菌和真菌培养也不显著。手术后开始使用大剂量全身类固醇。患者的VA恢复到20/30 OD和20/25 OS。结论:注射法利西单抗导致严重葡萄膜炎的报告已经被记录在案。我们描述了一个独特的情况下,患者肉芽肿性葡萄膜炎OU经历了视力显著下降。通过大剂量全身类固醇治疗和手术干预,VA恢复到接近基线。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bilateral Sterile Granulomatous Uveitis Caused by Intravitreal Injections of Faricimab.

Purpose: To describe a case of severe bilateral granulomatous uveitis caused by treatment with faricimab. Methods: A single case was reviewed. Results: A 79-year-old woman with diabetic macular edema developed severe uveitis OU 16 days after bilateral intravitreal (IVT) injections of faricimab. The patient's visual acuity (VA) was hand motions OD and 20/400 OS. She refused IVT antibiotics at bedside but consented to an emergency pars plana vitrectomy (PPV) OU. The laboratory workup for infectious and autoimmune etiologies was unremarkable, as were bacterial and fungal cultures from the PPV. High-dose systemic steroids were initiated after surgery. The patient's VA recovered to 20/30 OD and 20/25 OS. Conclusions: Reports of severe uveitis resulting from injections of faricimab have been documented. We describe a unique case in which the patient with granulomatous uveitis OU experienced a significant decline in vision. With high-dose systemic steroid therapy and surgical intervention, her VA recovered to near baseline.

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CiteScore
1.20
自引率
16.70%
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