Sheena Mariam Thomas, Jethendra Kumar Muruganantham, Praveen Kumar Chandra Sekar, B K Iyshwarya, Ramakrishnan Veerabathiran
{"title":"研究IKZF1 snp rs4132601和rs11978267对急性淋巴细胞白血病的影响：一项综合荟萃分析","authors":"Sheena Mariam Thomas, Jethendra Kumar Muruganantham, Praveen Kumar Chandra Sekar, B K Iyshwarya, Ramakrishnan Veerabathiran","doi":"10.1186/s43046-025-00274-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis investigates the association between acute lymphoblastic leukemia (ALL) susceptibility and IKZF1 gene SNPs.</p><p><strong>Methods: </strong>Utilizing EMBASE, PubMed, and other databases, the study evaluated methodological quality through the Newcastle-Ottawa Scale (NOS) scoring and Hardy-Weinberg Equilibrium (HWE) value. The present meta-analysis used Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Review Manager 5.4 software was employed for data analysis, emphasizing genetic variants' significance (p < 0.05). Visualizations were achieved using funnel and Circos plots.</p><p><strong>Results: </strong>A significant association was found between rs4132601 and ALL across genetic models, contrasting with the non-significant correlation for rs11978267. The findings underscore the complex interplay of genetic factors in ALL susceptibility, particularly related to IKZF1 SNPs. Ethnicity emphasizes the importance of diverse population considerations.</p><p><strong>Conclusion: </strong>This meta-analysis highlights the significance of rs4132601 in ALL's genetic foundation, suggesting potential advancements in diagnostics. The lack of correlation for rs11978267 highlights the complexity of its genetic association. Future studies should prioritize larger, diverse samples for a comprehensive understanding and improved strategies for ALL diagnoses and treatments.</p>","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"37 1","pages":"18"},"PeriodicalIF":2.1000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis.\",\"authors\":\"Sheena Mariam Thomas, Jethendra Kumar Muruganantham, Praveen Kumar Chandra Sekar, B K Iyshwarya, Ramakrishnan Veerabathiran\",\"doi\":\"10.1186/s43046-025-00274-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This meta-analysis investigates the association between acute lymphoblastic leukemia (ALL) susceptibility and IKZF1 gene SNPs.</p><p><strong>Methods: </strong>Utilizing EMBASE, PubMed, and other databases, the study evaluated methodological quality through the Newcastle-Ottawa Scale (NOS) scoring and Hardy-Weinberg Equilibrium (HWE) value. The present meta-analysis used Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Review Manager 5.4 software was employed for data analysis, emphasizing genetic variants' significance (p < 0.05). Visualizations were achieved using funnel and Circos plots.</p><p><strong>Results: </strong>A significant association was found between rs4132601 and ALL across genetic models, contrasting with the non-significant correlation for rs11978267. The findings underscore the complex interplay of genetic factors in ALL susceptibility, particularly related to IKZF1 SNPs. Ethnicity emphasizes the importance of diverse population considerations.</p><p><strong>Conclusion: </strong>This meta-analysis highlights the significance of rs4132601 in ALL's genetic foundation, suggesting potential advancements in diagnostics. The lack of correlation for rs11978267 highlights the complexity of its genetic association. Future studies should prioritize larger, diverse samples for a comprehensive understanding and improved strategies for ALL diagnoses and treatments.</p>\",\"PeriodicalId\":17301,\"journal\":{\"name\":\"Journal of the Egyptian National Cancer Institute\",\"volume\":\"37 1\",\"pages\":\"18\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Egyptian National Cancer Institute\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s43046-025-00274-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Egyptian National Cancer Institute","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s43046-025-00274-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis.
Objective: This meta-analysis investigates the association between acute lymphoblastic leukemia (ALL) susceptibility and IKZF1 gene SNPs.
Methods: Utilizing EMBASE, PubMed, and other databases, the study evaluated methodological quality through the Newcastle-Ottawa Scale (NOS) scoring and Hardy-Weinberg Equilibrium (HWE) value. The present meta-analysis used Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Review Manager 5.4 software was employed for data analysis, emphasizing genetic variants' significance (p < 0.05). Visualizations were achieved using funnel and Circos plots.
Results: A significant association was found between rs4132601 and ALL across genetic models, contrasting with the non-significant correlation for rs11978267. The findings underscore the complex interplay of genetic factors in ALL susceptibility, particularly related to IKZF1 SNPs. Ethnicity emphasizes the importance of diverse population considerations.
Conclusion: This meta-analysis highlights the significance of rs4132601 in ALL's genetic foundation, suggesting potential advancements in diagnostics. The lack of correlation for rs11978267 highlights the complexity of its genetic association. Future studies should prioritize larger, diverse samples for a comprehensive understanding and improved strategies for ALL diagnoses and treatments.
期刊介绍：
As the official publication of the National Cancer Institute, Cairo University, the Journal of the Egyptian National Cancer Institute (JENCI) is an open access peer-reviewed journal that publishes on the latest innovations in oncology and thereby, providing academics and clinicians a leading research platform. JENCI welcomes submissions pertaining to all fields of basic, applied and clinical cancer research. Main topics of interest include: local and systemic anticancer therapy (with specific interest on applied cancer research from developing countries); experimental oncology; early cancer detection; randomized trials (including negatives ones); and key emerging fields of personalized medicine, such as molecular pathology, bioinformatics, and biotechnologies.
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