Ícaro Guilherme Dos Santos, Marlon Ribeiro, João Paulo da Silva Cavasani, Luana Dias O Nascimento, Bernardo Nassau de Souza, Rafaela Mallmann-Bohn, Fábio Bernardo Schein, João Fabio Soares, Beatriz Souza Lima Nino, João Luis Garcia, Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Daniel Moura de Aguiar, Caroline Argenta Pescador
{"title":"巴西马托格罗索州发生一起由非典型基因型刚地弓形虫引起的绵羊流产病例。","authors":"Ícaro Guilherme Dos Santos, Marlon Ribeiro, João Paulo da Silva Cavasani, Luana Dias O Nascimento, Bernardo Nassau de Souza, Rafaela Mallmann-Bohn, Fábio Bernardo Schein, João Fabio Soares, Beatriz Souza Lima Nino, João Luis Garcia, Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Daniel Moura de Aguiar, Caroline Argenta Pescador","doi":"10.1007/s11259-025-10745-5","DOIUrl":null,"url":null,"abstract":"<p><p>Toxoplasma gondii is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of T. gondii-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil. The group of animals was comprised of 15 adult sheep, and one abortion was detected in a gestating ewe. T. gondii indirect immunofluorescence assay performed in serum samples yielded an antibody titer of 1:8192 in the affected dam indicating an acute phase of infection. The aborted fetus and placenta were submitted for necropsy. The only significant gross findings were the placental cotyledons with white foci. Microscopic findings included multifocal necrotizing encephalitis with intralesional protozoal cysts in the fetus's brain and moderate multifocal lymphoplasmacytic necrotizing placentitis. Tissue samples of the fetus and placenta had a positive PCR result for T. gondii. Restriction fragment length polymorphism (RFLP) genotyping using markers (SAG1, 5'-SAG2, 3'-SAG2, Alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO) was carried out and the results were consistent with an atypical genotype.</p>","PeriodicalId":23690,"journal":{"name":"Veterinary Research Communications","volume":"49 3","pages":"177"},"PeriodicalIF":1.8000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Description of a sheep abortion caused by atypical genotype of Toxoplasma gondii in the state of Mato Grosso, Brazil.\",\"authors\":\"Ícaro Guilherme Dos Santos, Marlon Ribeiro, João Paulo da Silva Cavasani, Luana Dias O Nascimento, Bernardo Nassau de Souza, Rafaela Mallmann-Bohn, Fábio Bernardo Schein, João Fabio Soares, Beatriz Souza Lima Nino, João Luis Garcia, Daniel Felipe Barrantes Murillo, Tatiane Terumi Negrão Watanabe, Daniel Moura de Aguiar, Caroline Argenta Pescador\",\"doi\":\"10.1007/s11259-025-10745-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Toxoplasma gondii is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of T. gondii-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil. The group of animals was comprised of 15 adult sheep, and one abortion was detected in a gestating ewe. T. gondii indirect immunofluorescence assay performed in serum samples yielded an antibody titer of 1:8192 in the affected dam indicating an acute phase of infection. The aborted fetus and placenta were submitted for necropsy. The only significant gross findings were the placental cotyledons with white foci. Microscopic findings included multifocal necrotizing encephalitis with intralesional protozoal cysts in the fetus's brain and moderate multifocal lymphoplasmacytic necrotizing placentitis. Tissue samples of the fetus and placenta had a positive PCR result for T. gondii. Restriction fragment length polymorphism (RFLP) genotyping using markers (SAG1, 5'-SAG2, 3'-SAG2, Alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO) was carried out and the results were consistent with an atypical genotype.</p>\",\"PeriodicalId\":23690,\"journal\":{\"name\":\"Veterinary Research Communications\",\"volume\":\"49 3\",\"pages\":\"177\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Research Communications\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1007/s11259-025-10745-5\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Research Communications","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1007/s11259-025-10745-5","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Description of a sheep abortion caused by atypical genotype of Toxoplasma gondii in the state of Mato Grosso, Brazil.
Toxoplasma gondii is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of T. gondii-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil. The group of animals was comprised of 15 adult sheep, and one abortion was detected in a gestating ewe. T. gondii indirect immunofluorescence assay performed in serum samples yielded an antibody titer of 1:8192 in the affected dam indicating an acute phase of infection. The aborted fetus and placenta were submitted for necropsy. The only significant gross findings were the placental cotyledons with white foci. Microscopic findings included multifocal necrotizing encephalitis with intralesional protozoal cysts in the fetus's brain and moderate multifocal lymphoplasmacytic necrotizing placentitis. Tissue samples of the fetus and placenta had a positive PCR result for T. gondii. Restriction fragment length polymorphism (RFLP) genotyping using markers (SAG1, 5'-SAG2, 3'-SAG2, Alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, and APICO) was carried out and the results were consistent with an atypical genotype.
期刊介绍：
Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial.
The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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