慢性胰腺炎的诊断和分期——内镜超声和经腹超声剪切波弹性成像诊断的准确性和一致性。

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2025-06-01 DOI:10.1016/j.dld.2025.03.013

Carlo Felix Maria Jung , Cecilia Binda , Elisa Liverani , Elton Dajti , Carmela Abbatiello , Ludovica Cristofaro , Luigina Vanessa Alemanni , Alessandro Sartini , Barbara Perini , Paolo Giuffrida , Chiara Coluccio , Giulia Gibiino , Stefano Fabbri , Carla Serra , Carlo Fabbri

{"title":"慢性胰腺炎的诊断和分期——内镜超声和经腹超声剪切波弹性成像诊断的准确性和一致性。","authors":"Carlo Felix Maria Jung , Cecilia Binda , Elisa Liverani , Elton Dajti , Carmela Abbatiello , Ludovica Cristofaro , Luigina Vanessa Alemanni , Alessandro Sartini , Barbara Perini , Paolo Giuffrida , Chiara Coluccio , Giulia Gibiino , Stefano Fabbri , Carla Serra , Carlo Fabbri","doi":"10.1016/j.dld.2025.03.013","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Diagnosis of chronic pancreatitis (CP) is invasive and depending on endoscopic ultrasound (EUS) evaluation using Rosemont Criteria (RC). Non invasive ultrasound (US) based tests are necessary to detect CP.</div></div><div><h3>Aim</h3><div>We compared transabdominal 2D Shear Wave Elastography (SWE) of the pancreas and the Gemelli Ultrasound Chronic Pancreatitis Score to EUS/RC for the diagnosis of chronic pancreatitis.</div></div><div><h3>Methods</h3><div>We conducted a single center prospective case-control study. EUS with RC defined cohorts with (<em>n</em> = 51) and without CP (<em>n</em> = 51). Patients underwent US evaluation of the pancreas using 2D SWE and USCP.</div></div><div><h3>Results</h3><div>Median SWE values were different between groups (no CP 1.45m/s; IQR 1.34–1.60 and with CP 1.72m/s; IQR 1.63–1.96; <em>p</em> < 0.0001) and different between RC subgroups (RC indeterminate for CP 1.67m/s, IQR 1.52–1.72 vs. RC suggestive 1.72m/s, IQR 1.62–1.97 vs. RC consistent with CP 1.90 m/s, IQR 1.72–2.12 m/s; <em>p</em> < 0.0001). Median USCP was different between groups. 2D SWE correlated with USCP (<em>p</em> < 0.0001) and RC (<em>p</em> < 0.0001). We defined a cut off SWE value of <1.42m/s to rule out CP (Sensitivity 96 %; NPV 92 %) and a SWE cut off >1.87m/s to diagnose CP (Specifity 96 %;PPV 90 %).</div></div><div><h3>Conclusion</h3><div>Pancreatic US evaluation with 2D SWE is a widely applicable and unexpensive tool for the diagnosis of CP. Larger studies are needed to confirm these results.</div></div>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":"57 6","pages":"Pages 1280-1287"},"PeriodicalIF":3.8000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnosis and staging of chronic pancreatitis-Diagnostic accuracy and agreement between endoscopic ultrasound and transabdominal ultrasound shear wave elastography\",\"authors\":\"Carlo Felix Maria Jung , Cecilia Binda , Elisa Liverani , Elton Dajti , Carmela Abbatiello , Ludovica Cristofaro , Luigina Vanessa Alemanni , Alessandro Sartini , Barbara Perini , Paolo Giuffrida , Chiara Coluccio , Giulia Gibiino , Stefano Fabbri , Carla Serra , Carlo Fabbri\",\"doi\":\"10.1016/j.dld.2025.03.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Diagnosis of chronic pancreatitis (CP) is invasive and depending on endoscopic ultrasound (EUS) evaluation using Rosemont Criteria (RC). Non invasive ultrasound (US) based tests are necessary to detect CP.</div></div><div><h3>Aim</h3><div>We compared transabdominal 2D Shear Wave Elastography (SWE) of the pancreas and the Gemelli Ultrasound Chronic Pancreatitis Score to EUS/RC for the diagnosis of chronic pancreatitis.</div></div><div><h3>Methods</h3><div>We conducted a single center prospective case-control study. EUS with RC defined cohorts with (<em>n</em> = 51) and without CP (<em>n</em> = 51). Patients underwent US evaluation of the pancreas using 2D SWE and USCP.</div></div><div><h3>Results</h3><div>Median SWE values were different between groups (no CP 1.45m/s; IQR 1.34–1.60 and with CP 1.72m/s; IQR 1.63–1.96; <em>p</em> < 0.0001) and different between RC subgroups (RC indeterminate for CP 1.67m/s, IQR 1.52–1.72 vs. RC suggestive 1.72m/s, IQR 1.62–1.97 vs. RC consistent with CP 1.90 m/s, IQR 1.72–2.12 m/s; <em>p</em> < 0.0001). Median USCP was different between groups. 2D SWE correlated with USCP (<em>p</em> < 0.0001) and RC (<em>p</em> < 0.0001). We defined a cut off SWE value of <1.42m/s to rule out CP (Sensitivity 96 %; NPV 92 %) and a SWE cut off >1.87m/s to diagnose CP (Specifity 96 %;PPV 90 %).</div></div><div><h3>Conclusion</h3><div>Pancreatic US evaluation with 2D SWE is a widely applicable and unexpensive tool for the diagnosis of CP. Larger studies are needed to confirm these results.</div></div>\",\"PeriodicalId\":11268,\"journal\":{\"name\":\"Digestive and Liver Disease\",\"volume\":\"57 6\",\"pages\":\"Pages 1280-1287\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Digestive and Liver Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1590865825002919\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1590865825002919","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：慢性胰腺炎（CP）的诊断是侵入性的，依赖于使用Rosemont标准（RC）的内镜超声（EUS）评估。目的：比较胰腺经腹二维剪切波弹性成像（SWE）和Gemelli超声慢性胰腺炎评分与EUS/RC对慢性胰腺炎的诊断价值。方法：采用单中心前瞻性病例对照研究。EUS与RC定义的队列，有（n = 51）和没有CP （n = 51）。患者使用2D SWE和USCP对胰腺进行US评估。结果：两组间SWE中位数有差异(无CP 1.45m/s；IQR为1.34 ~ 1.60，CP为1.72m/s；差1.63 - -1.96;p < 0.0001)，且不同亚型间存在差异(CP为1.67m/s的RC不确定，IQR为1.52-1.72，暗示为1.72m/s的RC不确定，IQR为1.62-1.97，CP为1.90 m/s的RC不确定，IQR为1.72-2.12 m/s；P < 0.0001)。中位USCP组间差异较大。2D SWE与USCP （p < 0.0001）和RC （p < 0.0001）相关。我们定义了1.87m/s的SWE截断值来诊断CP（特异性96%；PPV 90%）。结论：2D SWE胰腺US评估是一种广泛应用且价格低廉的诊断CP的工具，需要更大规模的研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Diagnosis and staging of chronic pancreatitis-Diagnostic accuracy and agreement between endoscopic ultrasound and transabdominal ultrasound shear wave elastography

Background

Diagnosis of chronic pancreatitis (CP) is invasive and depending on endoscopic ultrasound (EUS) evaluation using Rosemont Criteria (RC). Non invasive ultrasound (US) based tests are necessary to detect CP.

Aim

We compared transabdominal 2D Shear Wave Elastography (SWE) of the pancreas and the Gemelli Ultrasound Chronic Pancreatitis Score to EUS/RC for the diagnosis of chronic pancreatitis.

Methods

We conducted a single center prospective case-control study. EUS with RC defined cohorts with (n = 51) and without CP (n = 51). Patients underwent US evaluation of the pancreas using 2D SWE and USCP.

Results

Median SWE values were different between groups (no CP 1.45m/s; IQR 1.34–1.60 and with CP 1.72m/s; IQR 1.63–1.96; p < 0.0001) and different between RC subgroups (RC indeterminate for CP 1.67m/s, IQR 1.52–1.72 vs. RC suggestive 1.72m/s, IQR 1.62–1.97 vs. RC consistent with CP 1.90 m/s, IQR 1.72–2.12 m/s; p < 0.0001). Median USCP was different between groups. 2D SWE correlated with USCP (p < 0.0001) and RC (p < 0.0001). We defined a cut off SWE value of <1.42m/s to rule out CP (Sensitivity 96 %; NPV 92 %) and a SWE cut off >1.87m/s to diagnose CP (Specifity 96 %;PPV 90 %).

Conclusion

Pancreatic US evaluation with 2D SWE is a widely applicable and unexpensive tool for the diagnosis of CP. Larger studies are needed to confirm these results.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.