{"title":"18F-FLT PET评价1例中枢神经系统淋巴样肉芽肿病的疗效及复发。","authors":"Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yuka Yamamoto, Keisuke Miyake, Yoshihiro Nishiyama","doi":"10.1097/RLU.0000000000005953","DOIUrl":null,"url":null,"abstract":"<p><p>A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy. Brain PET examinations using 18F-fluorothymidine (FLT) PET and 11C-methionine (MET) PET were performed. Strong accumulation in the lesions was observed with 18F-FLT PET. After treatment, the accumulation of lesions disappeared, and accumulation was observed again at the time of recurrence. In contrast, 11C-MET PET showed unclear accumulation in the lesions both before therapy and at recurrence. 18F-FLT uptake was likely reflecting the degree of cell infiltration and the disrupted blood-brain barrier. 18F-FLT PET might be a useful tool for evaluating the therapeutic response and recurrence of CNS-LYG.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the Therapeutic Response and Recurrence by 18F-FLT PET in a Case of Central Nervous System-Lymphomatoid Granulomatosis.\",\"authors\":\"Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yuka Yamamoto, Keisuke Miyake, Yoshihiro Nishiyama\",\"doi\":\"10.1097/RLU.0000000000005953\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy. Brain PET examinations using 18F-fluorothymidine (FLT) PET and 11C-methionine (MET) PET were performed. Strong accumulation in the lesions was observed with 18F-FLT PET. After treatment, the accumulation of lesions disappeared, and accumulation was observed again at the time of recurrence. In contrast, 11C-MET PET showed unclear accumulation in the lesions both before therapy and at recurrence. 18F-FLT uptake was likely reflecting the degree of cell infiltration and the disrupted blood-brain barrier. 18F-FLT PET might be a useful tool for evaluating the therapeutic response and recurrence of CNS-LYG.</p>\",\"PeriodicalId\":10692,\"journal\":{\"name\":\"Clinical Nuclear Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/RLU.0000000000005953\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLU.0000000000005953","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Evaluation of the Therapeutic Response and Recurrence by 18F-FLT PET in a Case of Central Nervous System-Lymphomatoid Granulomatosis.
A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy. Brain PET examinations using 18F-fluorothymidine (FLT) PET and 11C-methionine (MET) PET were performed. Strong accumulation in the lesions was observed with 18F-FLT PET. After treatment, the accumulation of lesions disappeared, and accumulation was observed again at the time of recurrence. In contrast, 11C-MET PET showed unclear accumulation in the lesions both before therapy and at recurrence. 18F-FLT uptake was likely reflecting the degree of cell infiltration and the disrupted blood-brain barrier. 18F-FLT PET might be a useful tool for evaluating the therapeutic response and recurrence of CNS-LYG.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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