靶向线粒体治疗程序性心肌细胞死亡的机制。

IF 3.2 3区医学 Q2 PHYSIOLOGY

Frontiers in Physiology Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI:10.3389/fphys.2025.1548194

Fengting Jing, Min Zhao, Hemin Xiong, Xin Zeng, Jun Jiang, Tao Li

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引用次数: 0

摘要

心脏病是临床上常见的疾病，如心脏纤维化、心力衰竭、高血压、心律失常等。在全球范围内，心脏病的发病率和死亡率逐年上升。心脏病发生的主要机制与细胞状态有关。线粒体是细胞能量供应的器官，参与多种信号转导途径，在心脏病的发生发展中起着至关重要的作用。本文综述了与心脏病和线粒体功能障碍相关的细胞死亡模式和分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mechanisms underlying targeted mitochondrial therapy for programmed cardiac cell death.

Heart diseases are common clinical diseases, such as cardiac fibrosis, heart failure, hypertension and arrhythmia. Globally, the incidence rate and mortality of heart diseases are increasing by years. The main mechanism of heart disease is related to the cellular state. Mitochondrion is the organ of cellular energy supply, participating in various signal transduction pathways and playing a vital role in the occurrence and development of heart disease. This review summarizes the cell death patterns and molecular mechanisms associated with heart disease and mitochondrial dysfunction.

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来源期刊

Frontiers in Physiology PHYSIOLOGY-

CiteScore

6.50

自引率

5.00%

发文量

2608

审稿时长

14 weeks

期刊介绍： Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.