Robin Willixhofer, Massimo Mapelli, Nikita Baracchini, Nicola Campana, Teresa Maria Capovilla, Alessandro Nava, Elisabetta Salvioni, Carlo Vignati, Jeness Campodonico, Filippo Maria Rubbo, Damiano Magrì, Beatrice Pezzuto, Irene Mattavelli, Arianna Galotta, Nicolò Capra, Carriere Cosimo, Irena Tavčar, Maddalena Rossi, Christian Cadeddu, Marco Merlo, Gianfranco Sinagra, Piergiuseppe Agostoni
{"title":"合并肺功能检查与心肺运动检查对肥厚性心肌病的分层加强。","authors":"Robin Willixhofer, Massimo Mapelli, Nikita Baracchini, Nicola Campana, Teresa Maria Capovilla, Alessandro Nava, Elisabetta Salvioni, Carlo Vignati, Jeness Campodonico, Filippo Maria Rubbo, Damiano Magrì, Beatrice Pezzuto, Irene Mattavelli, Arianna Galotta, Nicolò Capra, Carriere Cosimo, Irena Tavčar, Maddalena Rossi, Christian Cadeddu, Marco Merlo, Gianfranco Sinagra, Piergiuseppe Agostoni","doi":"10.1136/heartjnl-2025-325737","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiopulmonary exercise testing (CPET) is essential for assessing patients with hypertrophic cardiomyopathy (HCM), but the role of pulmonary function testing (PFT) in refining patient stratification remains underexplored. This study investigates the relationship between PFT and CPET parameters in patients with HCM.</p><p><strong>Methods: </strong>In this prospective two-centre study, 102 clinically stable patients with HCM underwent PFT and CPET. Spearman's correlation and multiple linear regression were used to assess relationships between PFT (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV<sub>₁</sub>)) and CPET variables, adjusting for confounders.</p><p><strong>Results: </strong>Patients exhibited preserved lung function (mean FVC: 90.7%; FEV<sub>1</sub>: 92.5%). Strong correlations were observed between PFT and CPET metrics, including peak VO<sub>₂</sub> (FVC: r=0.649, p<0.001; FEV<sub>₁</sub>: r=0.691, p<0.001) and peak ventilation (FVC: r=0.682, p<0.001; FEV<sub>₁</sub>: r=0.688, p<0.001). Regression analysis confirmed independent associations between PFT and CPET performance (all p<0.001).</p><p><strong>Conclusion: </strong>PFT metrics strongly correlate with CPET parameters in HCM, suggesting that PFT could complement CPET for a more comprehensive assessment of exercise capacity and patient stratification.</p>","PeriodicalId":12835,"journal":{"name":"Heart","volume":" ","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in hypertrophic cardiomyopathy.\",\"authors\":\"Robin Willixhofer, Massimo Mapelli, Nikita Baracchini, Nicola Campana, Teresa Maria Capovilla, Alessandro Nava, Elisabetta Salvioni, Carlo Vignati, Jeness Campodonico, Filippo Maria Rubbo, Damiano Magrì, Beatrice Pezzuto, Irene Mattavelli, Arianna Galotta, Nicolò Capra, Carriere Cosimo, Irena Tavčar, Maddalena Rossi, Christian Cadeddu, Marco Merlo, Gianfranco Sinagra, Piergiuseppe Agostoni\",\"doi\":\"10.1136/heartjnl-2025-325737\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cardiopulmonary exercise testing (CPET) is essential for assessing patients with hypertrophic cardiomyopathy (HCM), but the role of pulmonary function testing (PFT) in refining patient stratification remains underexplored. This study investigates the relationship between PFT and CPET parameters in patients with HCM.</p><p><strong>Methods: </strong>In this prospective two-centre study, 102 clinically stable patients with HCM underwent PFT and CPET. Spearman's correlation and multiple linear regression were used to assess relationships between PFT (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV<sub>₁</sub>)) and CPET variables, adjusting for confounders.</p><p><strong>Results: </strong>Patients exhibited preserved lung function (mean FVC: 90.7%; FEV<sub>1</sub>: 92.5%). Strong correlations were observed between PFT and CPET metrics, including peak VO<sub>₂</sub> (FVC: r=0.649, p<0.001; FEV<sub>₁</sub>: r=0.691, p<0.001) and peak ventilation (FVC: r=0.682, p<0.001; FEV<sub>₁</sub>: r=0.688, p<0.001). Regression analysis confirmed independent associations between PFT and CPET performance (all p<0.001).</p><p><strong>Conclusion: </strong>PFT metrics strongly correlate with CPET parameters in HCM, suggesting that PFT could complement CPET for a more comprehensive assessment of exercise capacity and patient stratification.</p>\",\"PeriodicalId\":12835,\"journal\":{\"name\":\"Heart\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/heartjnl-2025-325737\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/heartjnl-2025-325737","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in hypertrophic cardiomyopathy.
Background: Cardiopulmonary exercise testing (CPET) is essential for assessing patients with hypertrophic cardiomyopathy (HCM), but the role of pulmonary function testing (PFT) in refining patient stratification remains underexplored. This study investigates the relationship between PFT and CPET parameters in patients with HCM.
Methods: In this prospective two-centre study, 102 clinically stable patients with HCM underwent PFT and CPET. Spearman's correlation and multiple linear regression were used to assess relationships between PFT (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV₁)) and CPET variables, adjusting for confounders.
Results: Patients exhibited preserved lung function (mean FVC: 90.7%; FEV1: 92.5%). Strong correlations were observed between PFT and CPET metrics, including peak VO₂ (FVC: r=0.649, p<0.001; FEV₁: r=0.691, p<0.001) and peak ventilation (FVC: r=0.682, p<0.001; FEV₁: r=0.688, p<0.001). Regression analysis confirmed independent associations between PFT and CPET performance (all p<0.001).
Conclusion: PFT metrics strongly correlate with CPET parameters in HCM, suggesting that PFT could complement CPET for a more comprehensive assessment of exercise capacity and patient stratification.
期刊介绍：
Heart is an international peer reviewed journal that keeps cardiologists up to date with important research advances in cardiovascular disease. New scientific developments are highlighted in editorials and put in context with concise review articles. There is one free Editor’s Choice article in each issue, with open access options available to authors for all articles. Education in Heart articles provide a comprehensive, continuously updated, cardiology curriculum.
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