胎盘增生谱生物学的最新进展和知识空白。

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Clinical obstetrics and gynecology Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI:10.1097/GRF.0000000000000929

Lior Kashani-Ligumsky, Olivia Scott, Guadalupe Martinez, Anhyo Jeong, Ophelia Yin, Sohum Shah, Amanda Wang, Yazhen Zhu, Yalda Afshar

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引用次数: 0

摘要

胎盘增生谱（PAS）疾病传统上以组织病理学分级为特征，强调滋养细胞侵入肌层和子宫浆膜。最近的研究已经改变了对PAS的病因学理解，从侵略性滋养细胞侵袭的概念转移到关注疤痕的蜕膜-肌层界面的关键作用。这一转变强调了瘢痕组织缺陷作为主要因素的重要性，重塑了预防策略、诊断准确性和治疗方法，以应对这种日益普遍的医源性和病态妊娠并发症。

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Updates and Knowledge Gaps in Placenta Accreta Spectrum Biology.

Placenta accreta spectrum (PAS) disorders have traditionally been characterized based on histopathologic grading, emphasizing the invasion of trophoblasts into the myometrium, and uterine serosa. Recent research has shifted the etiological understanding of PAS, moving away from the concept of aggressive trophoblast invasion to focusing on the critical role of scarred decidual-myometrial interface. This shift highlights the importance of defective scar tissue as a primary factor, reshaping prevention strategies, diagnostic accuracy, and treatment approaches for this increasingly prevalent iatrogenic and morbid pregnancy complication.

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来源期刊

Clinical obstetrics and gynecology 医学-妇产科学

CiteScore

2.70

自引率

0.00%

发文量

186

审稿时长

3 months

期刊介绍： Each issue of Clinical Obstetrics and Gynecology is a complete symposium on one or two timely topics of interest in obstetrics and gynecology. For each quarterly issue, two prominent guest editors solicit contributions on key clinical topics of interest to practicing physicians. Procedures, current clinical problems, medical and surgical treatments, and effective diagnostic aids are all carefully reviewed in original articles. The result is an instructive resource that dispenses trustworthy clinical guidance that enhances your understanding of key areas of your practice.