Udaya K Ranawaka, Chamila Mettananda, Sithumi Liyanage, Nethra De Silva, Jayalath Chandrasiri, Harsha Dharmasena, Sajeewanie Fernando, Sujeewani Kurukulasuriya, Arunasalam Pathmeswaran
{"title":"卒中后虚弱的患病率及其相关性：一项横断面研究。","authors":"Udaya K Ranawaka, Chamila Mettananda, Sithumi Liyanage, Nethra De Silva, Jayalath Chandrasiri, Harsha Dharmasena, Sajeewanie Fernando, Sujeewani Kurukulasuriya, Arunasalam Pathmeswaran","doi":"10.1159/000545884","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>There is little data on stroke and frailty, especially from South Asia. We aimed to study the prevalence and associations of post-stroke frailty in a cohort of stroke survivors.</p><p><strong>Methods: </strong>We studied all patients attending a tertiary care stroke clinic over 1 year (September 2023-August 2024). Patients with an index stroke event occurring 1 to 5 years earlier were included. Data on demographic features, stroke characteristics, functional outcome, and frailty were studied. Frailty was assessed with the Clinical Frailty Scale (CFS), stroke severity with the National Institute of Neurological Disorders and Stroke scale (NIHSS), and functional status with the modified Rankin Scale (mRS). Frailty was defined by a CFS score of ≥5 and functional dependence by an mRS score of 3-5. Strokes were categorized as mild (NIHSS score of 1-4), moderate (5-14), or severe (>14). Associations of post-stroke frailty were studied using logistic regression.</p><p><strong>Results: </strong>A total of 143 patients with stroke (mean age 58 ± 10 years, male 91 [63.6%]) with a mean follow-up of 2.7 (±1.6) years were studied. Of them, 141 (98%) were functionally independent before stroke onset. The majority (115 [80.4%]) had ischemic strokes, and 106 (74%) patients had moderate to severe strokes (admission NIHSS ≥5). On follow-up, 47 patients (33%) were frail (CFS ≥5), with 13 patients (9.1%) having moderate to severe frailty (CFS 6-9). Functional dependence on follow-up was seen in 33 patients (23%). Post-stroke frailty was independently associated with increasing age (p = 0.012), diabetes (p = 0.039), and admission stroke severity (p = 0.001) in a multivariable analysis. Biological sex, stroke type, other vascular risk factors, and duration of follow-up were not associated with post-stroke frailty.</p><p><strong>Conclusions: </strong>This is the first report on post-stroke frailty in South Asia. One-third of stroke survivors were frail on follow-up. Older age, diabetes and stroke severity were independent predictors of post-stroke frailty.</p>","PeriodicalId":9683,"journal":{"name":"Cerebrovascular Diseases","volume":" ","pages":"1-7"},"PeriodicalIF":1.5000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and Associations of Post-Stroke Frailty: A Cross-Sectional Study.\",\"authors\":\"Udaya K Ranawaka, Chamila Mettananda, Sithumi Liyanage, Nethra De Silva, Jayalath Chandrasiri, Harsha Dharmasena, Sajeewanie Fernando, Sujeewani Kurukulasuriya, Arunasalam Pathmeswaran\",\"doi\":\"10.1159/000545884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>There is little data on stroke and frailty, especially from South Asia. We aimed to study the prevalence and associations of post-stroke frailty in a cohort of stroke survivors.</p><p><strong>Methods: </strong>We studied all patients attending a tertiary care stroke clinic over 1 year (September 2023-August 2024). Patients with an index stroke event occurring 1 to 5 years earlier were included. Data on demographic features, stroke characteristics, functional outcome, and frailty were studied. Frailty was assessed with the Clinical Frailty Scale (CFS), stroke severity with the National Institute of Neurological Disorders and Stroke scale (NIHSS), and functional status with the modified Rankin Scale (mRS). Frailty was defined by a CFS score of ≥5 and functional dependence by an mRS score of 3-5. Strokes were categorized as mild (NIHSS score of 1-4), moderate (5-14), or severe (>14). Associations of post-stroke frailty were studied using logistic regression.</p><p><strong>Results: </strong>A total of 143 patients with stroke (mean age 58 ± 10 years, male 91 [63.6%]) with a mean follow-up of 2.7 (±1.6) years were studied. Of them, 141 (98%) were functionally independent before stroke onset. The majority (115 [80.4%]) had ischemic strokes, and 106 (74%) patients had moderate to severe strokes (admission NIHSS ≥5). On follow-up, 47 patients (33%) were frail (CFS ≥5), with 13 patients (9.1%) having moderate to severe frailty (CFS 6-9). Functional dependence on follow-up was seen in 33 patients (23%). Post-stroke frailty was independently associated with increasing age (p = 0.012), diabetes (p = 0.039), and admission stroke severity (p = 0.001) in a multivariable analysis. Biological sex, stroke type, other vascular risk factors, and duration of follow-up were not associated with post-stroke frailty.</p><p><strong>Conclusions: </strong>This is the first report on post-stroke frailty in South Asia. One-third of stroke survivors were frail on follow-up. Older age, diabetes and stroke severity were independent predictors of post-stroke frailty.</p>\",\"PeriodicalId\":9683,\"journal\":{\"name\":\"Cerebrovascular Diseases\",\"volume\":\" \",\"pages\":\"1-7\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cerebrovascular Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545884\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebrovascular Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545884","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Prevalence and Associations of Post-Stroke Frailty: A Cross-Sectional Study.
Introduction: There is little data on stroke and frailty, especially from South Asia. We aimed to study the prevalence and associations of post-stroke frailty in a cohort of stroke survivors.
Methods: We studied all patients attending a tertiary care stroke clinic over 1 year (September 2023-August 2024). Patients with an index stroke event occurring 1 to 5 years earlier were included. Data on demographic features, stroke characteristics, functional outcome, and frailty were studied. Frailty was assessed with the Clinical Frailty Scale (CFS), stroke severity with the National Institute of Neurological Disorders and Stroke scale (NIHSS), and functional status with the modified Rankin Scale (mRS). Frailty was defined by a CFS score of ≥5 and functional dependence by an mRS score of 3-5. Strokes were categorized as mild (NIHSS score of 1-4), moderate (5-14), or severe (>14). Associations of post-stroke frailty were studied using logistic regression.
Results: A total of 143 patients with stroke (mean age 58 ± 10 years, male 91 [63.6%]) with a mean follow-up of 2.7 (±1.6) years were studied. Of them, 141 (98%) were functionally independent before stroke onset. The majority (115 [80.4%]) had ischemic strokes, and 106 (74%) patients had moderate to severe strokes (admission NIHSS ≥5). On follow-up, 47 patients (33%) were frail (CFS ≥5), with 13 patients (9.1%) having moderate to severe frailty (CFS 6-9). Functional dependence on follow-up was seen in 33 patients (23%). Post-stroke frailty was independently associated with increasing age (p = 0.012), diabetes (p = 0.039), and admission stroke severity (p = 0.001) in a multivariable analysis. Biological sex, stroke type, other vascular risk factors, and duration of follow-up were not associated with post-stroke frailty.
Conclusions: This is the first report on post-stroke frailty in South Asia. One-third of stroke survivors were frail on follow-up. Older age, diabetes and stroke severity were independent predictors of post-stroke frailty.
期刊介绍：
A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.
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