单个和集体细胞运动的建模和模拟。

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Jupiter Algorta, Ali Fele-Paranj, Jack M Hughes, Leah Edelstein-Keshet
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引用次数: 0

摘要

我们调查了真核细胞迁移的经典和最近的实验和建模发展的组合,从亚细胞过程和调控,到单个和集体细胞动力学。我们展示了几个例子,在几个层次上演示了模拟:亚细胞肌动蛋白波,相应的迁移细胞行为,以及几个多细胞系统的集体行为。我们认为,使用共享的开源软件包(如Morpheus,在我们的案例中)来模拟多尺度模型对社区来说是一个福音,允许我们重新创建、调查和构建现有的工作。提供了当前可用软件的简要摘要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modeling and Simulating Single and Collective Cell Motility.

We survey a combination of classical and recent experimental and modeling developments in eukaryotic cell migration, from the subcellular processes and regulation, to single and collective cell dynamics. We showcase several examples that demonstrate simulations at several hierarchies: subcellular actin waves, corresponding migratory cell behavior, and collective behavior of several multicellular systems. We argue that the use of shared open-source software packages (such as Morpheus, in our case) to simulate multiscale models would be a boon to the community, allowing us to recreate, investigate, and build on existing work. A brief summary of currently available software is provided.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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