血浆干扰素-γ水平与肺结核感染筛查孕妇子痫前期的关系

IF 8.5 1区医学 Q1 INFECTIOUS DISEASES

Clinical Microbiology and Infection Pub Date : 2025-04-22 DOI:10.1016/j.cmi.2025.04.015

John Walles , Niclas Winqvist , Stefan R. Hansson , Erik Sturegård , Haitham Baqir , Torbjörn Kjerstadius , Thomas Schön , Per Björkman

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引用次数: 0

摘要

目的：妊娠对结核分枝杆菌感染（MtbI）免疫控制的影响。我们最近报道了MtbI与妊娠并发症之间的关联，特别是严重的先兆子痫，在一个基于登记的队列中，来自肺结核流行国家的妇女在瑞典产前保健中筛查了MtbI，这意味着MtbI对先兆子痫的发展有潜在的作用。在这里，我们的目的是研究血浆干扰素γ分泌作为这种相互作用的潜在介质的作用。方法：比较MtbI妇女（定义为没有结核病的QuantiFERON阳性结果）和MtbI阴性妇女在子痫前期和严重子痫前期诊断中的血浆干扰素-γ水平。比较研究人群中MtbI状态和干扰素-γ水平（0.28 IU/mL） 90百分位数的子痫前期和重度子痫前期的几率。结果：3605例女性中有700例（19.4%）检测到MtbI， 110例（3.1%）诊断为子痫前期，其中50例（1.4%）为重度子痫前期。MtbI患者的干扰素-γ水平高于MtbI阴性患者(中位数0.12 IU/mL，四分位数间距[IQR] 0.06-0.26；vs. 0.07 IU/mL, IQR 0.04-0.12；与使用干扰素-γ的MtbI阴性妇女相比，使用干扰素-γ 0.28 IU/mL的MtbI阴性妇女发生子痫前期或严重子痫前期的几率增加。结论：这些发现表明，干扰素-γ分泌可能在MtbI与子痫前期发展之间起中介作用。

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Association between plasma interferon-γ levels and preeclampsia in pregnant women screened for tuberculosis infection

Objectives

Pregnancy can influence immune control of Mycobacterium tuberculosis infection (MtbI). We recently reported an association between MtbI and pregnancy complications, particularly severe preeclampsia, in a registry-based cohort of women originating in tuberculosis-endemic countries screened for MtbI in Swedish antenatal care, implying a potential role of MtbI for the development of preeclampsia. Here, we aimed to investigate the role of plasma interferon-γ secretion as a potential mediator of this interaction.

Methods

Plasma interferon-γ levels were compared with women with MtbI (defined as positive QuantiFERON results in the absence of tuberculosis) and MtbI-negative women regarding any diagnosis of preeclampsia and severe preeclampsia. Odds of preeclampsia and severe preeclampsia were compared with respect to MtbI status and interferon-γ levels >90th percentile in the study population (0.28 IU/mL).

Results

MtbI was detected in 700 of 3605 women (19.4%) and preeclampsia was diagnosed in 110 (3.1%), among whom 50 (1.4%) had severe preeclampsia. Women with MtbI had higher interferon-γ levels than MtbI-negative women (median 0.12 IU/mL, interquartile range [IQR], 0.06–0.26 IU/mL; vs. 0.07 IU/mL, IQR 0.04–0.12 IU/mL; p < 0.001). The prevalence of preeclampsia of any grade (13/159, 8.2%, odds ratio [OR], 2.79; 95% CI, 1.52–5.12; p < 0.001) and severe preeclampsia (10/159, 6.3%, OR, 5.46; 95% CI, 2.64–11.3; p < 0.0001) was higher in women with MtbI and interferon-γ levels >0.28 IU/mL, than in MtbI-negative women with interferon-γ levels <0.28 IU/mL. Neither women with MtbI with interferon-γ levels <0.28 IU/mL, nor MtbI-negative women with interferon-γ levels >0.28 IU/mL, had increased odds of preeclampsia or severe preeclampsia compared to MtbI-negative women with interferon-γ levels <0.28 IU/mL.

Discussion

These findings suggest that interferon-γ secretion could be involved as a mediator in the association between MtbI and development of preeclampsia.

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来源期刊

Clinical Microbiology and Infection 医学-传染病学

CiteScore

25.30

自引率

2.10%

发文量

441

审稿时长

2-4 weeks

期刊介绍： Clinical Microbiology and Infection (CMI) is a monthly journal published by the European Society of Clinical Microbiology and Infectious Diseases. It focuses on peer-reviewed papers covering basic and applied research in microbiology, infectious diseases, virology, parasitology, immunology, and epidemiology as they relate to therapy and diagnostics.