Laia Oliveras, Laura Pareja, Josepa Ribes, Jordi Comas, Carlos Couceiro, Àlex Favà, Sergi Codina, Ana Coloma, Anna Manonelles, Nuria Lloberas, Edoardo Melilli, Elisenda Martinez-Carbonell, Jordi Gálvez, Sonia Mosteiro, Jaume Tort, Josep M Borràs, Josep M Cruzado, Nuria Montero
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引用次数: 0
摘要
背景：与一般人群中年龄和性别匹配的个体相比，肾衰竭患者患癌症的风险更高，但来自南欧的数据有限。本研究探讨了加泰罗尼亚地区肾衰竭人群的癌症发病率。方法：我们通过连接加泰罗尼亚肾脏登记处和加泰罗尼亚癌症数据库来确定癌症病例。计算了透析和肾移植患者的全部位和特定部位癌症的标准化发病率（SIRs）。结果：我们描述了2003-21年加泰罗尼亚地区21,595名透析患者和8037名肾移植患者的癌症流行病学。与一般人群相比，透析患者的癌症风险高出两倍多（SIR 2.11, 95% CI 2.02-2.19），肾移植患者的癌症风险高出近四倍（SIR 3.82, 95% CI 3.65-3.99）。风险因癌症部位而异，透析组中肾癌和甲状腺癌的发生率明显较高，移植组中皮肤癌的发生率明显较高。最年轻的患者、肾小球疾病患者和移植后时间最长的患者患癌风险最高。结论：肾衰竭患者面临较高的癌症负担，尤其是肾移植后。了解肾衰竭人群中癌症的流行病学对制定卫生政策至关重要。
Cancer risks in people on dialysis and kidney transplant recipients: a Catalan cohort study, 2003-21.
Background: People with kidney failure have a higher risk of cancer compared with age- and sex-matched individuals in the general population, yet data from southern Europe are limited. This study explores cancer incidence in the kidney failure population in Catalonia.
Methods: We identified cancer cases through linkage of the Catalan Kidney Registry with Catalan cancer databases. Standardized incidence ratios (SIRs) were calculated for all-site and site-specific cancers in people on dialysis and kidney transplant recipients.
Results: We described the epidemiology of cancer in 21 595 people on dialysis and 8037 kidney transplant recipients in Catalonia (2003-21). Cancer risk was more than two times higher in people on dialysis (SIR 2.11, 95% CI 2.02-2.19) and nearly four times higher in kidney transplant recipients (SIR 3.82, 95% CI 3.65-3.99) compared with the general population. Risks varied by cancer site, with a significantly higher incidence of kidney and thyroid cancers in the dialysis cohort, and skin cancer in the transplant cohort. The highest cancer risks were observed in the youngest, those with glomerular diseases, and those with the longest time since transplantation.
Conclusions: People with kidney failure face a high burden of cancer, particularly after kidney transplantation. Understanding the epidemiology of cancer in the kidney failure population is crucial for shaping health policies.
期刊介绍：
About the Journal
Clinical Kidney Journal: Clinical and Translational Nephrology (ckj), an official journal of the ERA-EDTA (European Renal Association-European Dialysis and Transplant Association), is a fully open access, online only journal publishing bimonthly. The journal is an essential educational and training resource integrating clinical, translational and educational research into clinical practice. ckj aims to contribute to a translational research culture among nephrologists and kidney pathologists that helps close the gap between basic researchers and practicing clinicians and promote sorely needed innovation in the Nephrology field. All research articles in this journal have undergone peer review.
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