N A Bondarenko, M A Surovtseva, I I Kim, S V Ostapets, O S Kosareva, M N Drovosekov, O V Poveshchenko
{"title":"来自Bichat脂肪垫、骨髓和脂肪组织的间充质干细胞用于骨组织再生功能潜力的比较评估。","authors":"N A Bondarenko, M A Surovtseva, I I Kim, S V Ostapets, O S Kosareva, M N Drovosekov, O V Poveshchenko","doi":"10.1007/s10517-025-06378-y","DOIUrl":null,"url":null,"abstract":"<p><p>The functional potential of mesenchymal stem cells (MSC) isolated from Bichat's fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat's fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat's fat pad makes them promising for cell therapy, including osteoinduction in dentistry.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"581-585"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat's Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration.\",\"authors\":\"N A Bondarenko, M A Surovtseva, I I Kim, S V Ostapets, O S Kosareva, M N Drovosekov, O V Poveshchenko\",\"doi\":\"10.1007/s10517-025-06378-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The functional potential of mesenchymal stem cells (MSC) isolated from Bichat's fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat's fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat's fat pad makes them promising for cell therapy, including osteoinduction in dentistry.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\"178 5\",\"pages\":\"581-585\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06378-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06378-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat's Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration.
The functional potential of mesenchymal stem cells (MSC) isolated from Bichat's fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat's fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat's fat pad makes them promising for cell therapy, including osteoinduction in dentistry.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
