肾病学中的多组学整合：进展、挑战和未来方向。

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2025-04-11 DOI:10.1016/j.semnephrol.2025.151584

Afaf Saliba, Yuheng Du, Tianqing Feng, Lana Garmire

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引用次数: 0

摘要

组学技术已经改变了肾脏病学，为肾脏疾病的分子机制提供了深入的见解，并使更精确的诊断工具、治疗策略和预后标记成为可能。多组学数据集成，跨越体组学、单细胞组学和空间组学，为健康和疾病中的肾脏生物学提供了全面的视角。在这篇综述中，我们探讨了整合转录组学、表观基因组学和空间数据的方法和挑战。通过组合组学层，研究人员可以发现新的分子相互作用和空间组织组织，促进我们对糖尿病肾病和常染色体多囊肾病等疾病的理解。这种综合方法正在重塑肾脏病学的诊断和治疗策略，对于优化空间和多组学分析的见解至关重要。Semin Nephrol 36:x-xx©20xx Elsevier Inc.。版权所有。

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Multi-Omics Integration in Nephrology: Advances, Challenges, and Future Directions.

Omics technologies have transformed nephrology, providing deep insights into molecular mechanisms of kidney disease and enabling more precise diagnostic tools, therapeutic strategies, and prognostic markers. Multi-omics data integration, spanning bulk, single-cell, and spatial omics, offers a comprehensive view of kidney biology in health and disease. In this review, we explore methods and challenges for integrating transcriptomic, epigenomic, and spatial data. By combining omics layers, researchers can uncover novel molecular interactions and spatial tissue organization, advancing our understanding of diseases like diabetic kidney disease and autosomal polycystic kidney disease. This integrated approach is reshaping diagnostic and therapeutic strategies in nephrology and is critical for optimizing insights available from spatial and multi-omics analysis. Semin Nephrol 36:x-xx © 20xx Elsevier Inc. All rights reserved.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.