Pau Rosés-Gibert, Jean-Luc Perrot, Javiera Pérez-Anker, Christian Dorado Cortez, Carmen Orte Cano, Elisa Cinotti, Véronique Del Marmol, Margot Fontaine, Jilliana Monnier, Pietro Rubegni, Linda Tognetti, Mariano Suppa, Susana Puig, Josep Malvehy
{"title":"革命性的离体皮肤成像：用离体LC-OCT对皮肤肿瘤进行三维表征。一项初步研究。","authors":"Pau Rosés-Gibert, Jean-Luc Perrot, Javiera Pérez-Anker, Christian Dorado Cortez, Carmen Orte Cano, Elisa Cinotti, Véronique Del Marmol, Margot Fontaine, Jilliana Monnier, Pietro Rubegni, Linda Tognetti, Mariano Suppa, Susana Puig, Josep Malvehy","doi":"10.1159/000545960","DOIUrl":null,"url":null,"abstract":"<p><p>Introduction Numerous imaging techniques, such as Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), and Line-field Confocal OCT (LC-OCT), are available for skin evaluation. However, there remains a need for improved imaging methods to better understand tumor histology and enhance surgical margin detection. This study aimed to evaluate the quality of ex vivo LC-OCT images in cutaneous tumors, describe their morphological features, and correlate the findings with dermoscopy, in vivo RCM, and histology.</p><p><strong>Methods: </strong>A prospective study was conducted from June 2022 to July 2023, including patients aged ≥18 years with cutaneous tumors on the trunk or limbs. Clinical, dermoscopic, RCM, ex vivo LC-OCT, and histopathological images were collected from 10 tumors, including melanomas, seborrheic keratoses, basal cell carcinomas, and melanocytic nevi.</p><p><strong>Results: </strong>Ex vivo LC-OCT produced high-quality images equivalent to those from in vivo devices, enabling three-dimensional visualization of excised tumors. The images displayed cellular resolution with strong correlations to confocal microscopy and histology.</p><p><strong>Conclusions: </strong>Ex vivo LC-OCT shows promise for improving the evaluation of cutaneous tumors and may enhance dermato-oncological surgery, particularly in margin control.</p>","PeriodicalId":11185,"journal":{"name":"Dermatology","volume":" ","pages":"1-18"},"PeriodicalIF":3.0000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revolutionizing ex vivo skin imaging: 3D characterization of skin tumors with ex vivo LC-OCT. A pilot study.\",\"authors\":\"Pau Rosés-Gibert, Jean-Luc Perrot, Javiera Pérez-Anker, Christian Dorado Cortez, Carmen Orte Cano, Elisa Cinotti, Véronique Del Marmol, Margot Fontaine, Jilliana Monnier, Pietro Rubegni, Linda Tognetti, Mariano Suppa, Susana Puig, Josep Malvehy\",\"doi\":\"10.1159/000545960\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Introduction Numerous imaging techniques, such as Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), and Line-field Confocal OCT (LC-OCT), are available for skin evaluation. However, there remains a need for improved imaging methods to better understand tumor histology and enhance surgical margin detection. This study aimed to evaluate the quality of ex vivo LC-OCT images in cutaneous tumors, describe their morphological features, and correlate the findings with dermoscopy, in vivo RCM, and histology.</p><p><strong>Methods: </strong>A prospective study was conducted from June 2022 to July 2023, including patients aged ≥18 years with cutaneous tumors on the trunk or limbs. Clinical, dermoscopic, RCM, ex vivo LC-OCT, and histopathological images were collected from 10 tumors, including melanomas, seborrheic keratoses, basal cell carcinomas, and melanocytic nevi.</p><p><strong>Results: </strong>Ex vivo LC-OCT produced high-quality images equivalent to those from in vivo devices, enabling three-dimensional visualization of excised tumors. The images displayed cellular resolution with strong correlations to confocal microscopy and histology.</p><p><strong>Conclusions: </strong>Ex vivo LC-OCT shows promise for improving the evaluation of cutaneous tumors and may enhance dermato-oncological surgery, particularly in margin control.</p>\",\"PeriodicalId\":11185,\"journal\":{\"name\":\"Dermatology\",\"volume\":\" \",\"pages\":\"1-18\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545960\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545960","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
Revolutionizing ex vivo skin imaging: 3D characterization of skin tumors with ex vivo LC-OCT. A pilot study.
Introduction Numerous imaging techniques, such as Reflectance Confocal Microscopy (RCM), Optical Coherence Tomography (OCT), and Line-field Confocal OCT (LC-OCT), are available for skin evaluation. However, there remains a need for improved imaging methods to better understand tumor histology and enhance surgical margin detection. This study aimed to evaluate the quality of ex vivo LC-OCT images in cutaneous tumors, describe their morphological features, and correlate the findings with dermoscopy, in vivo RCM, and histology.
Methods: A prospective study was conducted from June 2022 to July 2023, including patients aged ≥18 years with cutaneous tumors on the trunk or limbs. Clinical, dermoscopic, RCM, ex vivo LC-OCT, and histopathological images were collected from 10 tumors, including melanomas, seborrheic keratoses, basal cell carcinomas, and melanocytic nevi.
Results: Ex vivo LC-OCT produced high-quality images equivalent to those from in vivo devices, enabling three-dimensional visualization of excised tumors. The images displayed cellular resolution with strong correlations to confocal microscopy and histology.
Conclusions: Ex vivo LC-OCT shows promise for improving the evaluation of cutaneous tumors and may enhance dermato-oncological surgery, particularly in margin control.
期刊介绍：
Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.
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