Nomenclature for Factors of the HLA System, Update January, February and March 2025

The following sequences have been submitted to the Nomenclature Committee since the October, November and December 2024 nomenclature update (Marsh, 2025) and, following agreed policy, have been assigned official allele designations (Marsh et al. 2010). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

An N suffix was added to the DRB4*01:03:01:26 allele in February 2025, now making it DRB4*01:03:01:26N, as this allele was shown to have the same splice mutation as was previously reported in the DRB4*01:03:01:02N allele.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLA Database using the sequence submission tool provided (Barker et al. 2023; Robinson et al. 2024). The IPD-IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla