由一种酶从负霉素生物合成途径直接形成氮-氮键

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2025-05-15 DOI:10.1038/s41589-025-01899-z

引用次数: 0

摘要

Negamcyin是一种有几十年历史的抗生素，是开发治疗革兰氏阴性病原体和遗传性疾病的药物的有希望的先导化合物。我们鉴定了它的生物合成基因簇，发现了一个新的血红素依赖酶，它直接由甘氨酸和亚硝酸盐形成氮-氮键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct nitrogen–nitrogen bond formation by an enzyme from the negamycin biosynthetic pathway

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Direct nitrogen–nitrogen bond formation by an enzyme from the negamycin biosynthetic pathway

Negamcyin, a decades-old antibiotic, is a promising lead compound for the development of drugs for treatment of Gram-negative pathogens and hereditary diseases. We identified its biosynthetic gene cluster and found a new heme-dependent enzyme that directly forms its nitrogen–nitrogen bond from glycine and nitrite.

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.