烧伤患者血清白蛋白水平与临床结局的关系:一项单中心回顾性分析。

Maryam Ramezanian, Parissa Bagheri Toolaroud, Cyrus Emiralavi, Mohaya Farzin, Mohammadreza Mobayen, Moein Moghaddam Ahmadi, Mohammad Tolouei, Siamak Rimaz, Mehdi Karimian, Hojat Eftekhari, Kiana Baghi, Ali Shabbak
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引用次数: 0

摘要

目的:严重烧伤常导致明显的血管内白蛋白丢失,导致低白蛋白血症。本研究旨在评估烧伤患者血清白蛋白水平与临床预后之间的关系。方法:在Velayat医院(Rasht, Iran)进行了一项回顾性单中心研究,纳入了2019年4月至2020年3月期间入院的年龄≥16岁的烧伤患者。分别于第1天、第7天和出院时记录血清白蛋白水平。分析的主要变量包括白蛋白水平、住院时间、植皮率、机械通气需求和死亡率。结果:纳入研究的74例患者中,死亡14例(18.9%),存活60例(81.1%)。存活组在第1、7和出院时的平均血清白蛋白水平(分别为3.09±0.22、3.12±0.23和3.18±0.28 g/dL)均显著高于非存活组(分别为2.22±0.29、2.74±0.29和2.07±0.69 g/dL) (pp=0.03)。此外,血清白蛋白水平与烧伤总体表面积(TBSA)和移植物范围呈显著负相关(第1天:rs=-0.76,第7天:rs=-0.74,出院:rs=-0.62;Ps =-0.59,第7天rs=-0.58,放电rs=-0.50;结论:低白蛋白血症与严重烧伤患者的不良临床预后相关。血清白蛋白水平可作为烧伤严重程度的特定标记和死亡率的预测因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Serum Albumin Levels and Clinical Outcomes in Burn Patients: A Single-center Retrospective Analysis.

Objectives: Severe burns often result in significant intravascular albumin loss, leading to hypoalbuminemia. This study aimed to evaluate the association between serum albumin levels and clinical outcomes in burn patients.

Methods: A retrospective, single-center study was conducted at Velayat Hospital (Rasht, Iran), including burn patients aged ≥16 years, who were admitted between April 2019 and March 2020. Serum albumin levels were recorded on day 1, day 7, and at discharge. The main variables analyzed included albumin levels, length of hospital stay, skin graft rate, need for mechanical ventilation, and mortality.

Results: Among the 74 patients included in the study, 14 (18.9%) died, while 60 (81.1%) survived. The mean serum albumin levels on days 1, 7, and at discharge were significantly higher in survivors (3.09±0.22, 3.12±0.23, and 3.18±0.28 g/dL, respectively) than non-survivors (2.22±0.29, 2.74±0.29, and 2.07±0.69 g/dL, respectively) at all time points (p<0.001). The serum albumin level measured on day 1 was significantly lower in patients who required mechanical ventilation than in those who did not (2.86±0.47 vs.3.09±0.13, p=0.03). Additionally, a significant inverse relationship was observed between serum albumin levels and both total body surface area burned (TBSA) and graft extent (day 1: rs=-0.76, day 7: rs=-0.74, discharge: rs=-0.62; p<0.001 for TBSA; and day 1: rs=-0.59, day 7: rs=-0.58, discharge: rs=-0.50; p<0.001 for graft extent).

Conclusion: Hypoalbuminemia was associated with poor clinical outcomes in patients with severe burns. Serum albumin levels might serve as a specific marker of burn severity and a predictor of mortality.

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来源期刊
自引率
0.00%
发文量
49
审稿时长
12 weeks
期刊介绍: BEAT: Bulletin of Emergency And Trauma is an international, peer-reviewed, quarterly journal coping with original research contributing to the field of emergency medicine and trauma. BEAT is the official journal of the Trauma Research Center (TRC) of Shiraz University of Medical Sciences (SUMS), Hungarian Trauma Society (HTS) and Lusitanian Association for Trauma and Emergency Surgery (ALTEC/LATES) aiming to be a publication of international repute that serves as a medium for dissemination and exchange of scientific knowledge in the emergency medicine and trauma. The aim of BEAT is to publish original research focusing on practicing and training of emergency medicine and trauma to publish peer-reviewed articles of current international interest in the form of original articles, brief communications, reviews, case reports, clinical images, and letters.
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