{"title":"PIVKA-II异常升高1例。","authors":"Gangfeng Li, Tao Lu, Qiong Wang","doi":"10.7754/Clin.Lab.2024.241054","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) is a serum biomarker that is specifically elevated in hepatocellular carcinoma (HCC) and has important value in early diagnosis, prognosis evaluation, and recurrence prediction of liver cancer.</p><p><strong>Methods: </strong>We report a case of extreme elevation of serum PIVKA-II due to the use of warfarin.</p><p><strong>Results: </strong>The patient's abdominal ultrasound and enhanced CT examinations showed no significant abnormalities. The patient has been taking warfarin for atrial fibrillation, and after supplementing with vitamin K, the PIVKA-II level significantly decreased. Therefore, the PIVKA-II results were extremely elevated, which is believed to be caused by taking warfarin.</p><p><strong>Conclusions: </strong>When patients take warfarin anticoagulant therapy, it may cause an extreme increase in PIVKA-II results. Laboratory staff and clinical doctors should consider the existence of this situation and avoid unnecessary examinations and treatments for patients.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 4","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"One Case of Abnormal Elevation of PIVKA-II.\",\"authors\":\"Gangfeng Li, Tao Lu, Qiong Wang\",\"doi\":\"10.7754/Clin.Lab.2024.241054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) is a serum biomarker that is specifically elevated in hepatocellular carcinoma (HCC) and has important value in early diagnosis, prognosis evaluation, and recurrence prediction of liver cancer.</p><p><strong>Methods: </strong>We report a case of extreme elevation of serum PIVKA-II due to the use of warfarin.</p><p><strong>Results: </strong>The patient's abdominal ultrasound and enhanced CT examinations showed no significant abnormalities. The patient has been taking warfarin for atrial fibrillation, and after supplementing with vitamin K, the PIVKA-II level significantly decreased. Therefore, the PIVKA-II results were extremely elevated, which is believed to be caused by taking warfarin.</p><p><strong>Conclusions: </strong>When patients take warfarin anticoagulant therapy, it may cause an extreme increase in PIVKA-II results. Laboratory staff and clinical doctors should consider the existence of this situation and avoid unnecessary examinations and treatments for patients.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 4\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2024.241054\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.241054","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
Background: Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) is a serum biomarker that is specifically elevated in hepatocellular carcinoma (HCC) and has important value in early diagnosis, prognosis evaluation, and recurrence prediction of liver cancer.
Methods: We report a case of extreme elevation of serum PIVKA-II due to the use of warfarin.
Results: The patient's abdominal ultrasound and enhanced CT examinations showed no significant abnormalities. The patient has been taking warfarin for atrial fibrillation, and after supplementing with vitamin K, the PIVKA-II level significantly decreased. Therefore, the PIVKA-II results were extremely elevated, which is believed to be caused by taking warfarin.
Conclusions: When patients take warfarin anticoagulant therapy, it may cause an extreme increase in PIVKA-II results. Laboratory staff and clinical doctors should consider the existence of this situation and avoid unnecessary examinations and treatments for patients.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
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