眼表鳞状细胞瘤:侵袭性生长行为的危险因素和Ki-67的作用。

IF 3.3 4区 医学 Q1 OPHTHALMOLOGY
Anna Schuh, Medea Ettl, Siegfried Priglinger, Elisabeth M Messmer, Andreas Ohlmann, Christoph Hintschich
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引用次数: 0

摘要

目的:分析眼表鳞状细胞瘤(OSSN)的初诊特点及侵袭性生长行为的潜在危险因素。设计:回顾性。方法:纳入2013年至2022年在某三级中心首次诊断为OSSN的患者。分析病例的人口统计学、临床表现和组织病理学结果,包括Ki-67表达。结果:共纳入153例首次诊断为组织病理学证实的OSSN患者。平均年龄72岁(36-98岁),男性稍占优势(66%;n = 101)。大多数患者为浸润性鳞状细胞癌(SCC);45.8%, 70),其次是原位癌(CIS;37.9%, 58)和上皮发育不良(ED;16.3%, 25)。症状持续时间差异显著:ED 6个月(0-36),CIS 1.5个月(0-48),SCC 3个月(0-36)(p = 0.048)。44.3%(51/115)的病例以前被误诊,因此没有得到充分治疗。在最初诊断时,眼眶受累率为8.5%(13例),眼内受累率为1.3%(2例),转移率为2.7%(4例)。Ki-67标记指数(LI)在不同亚型之间差异显著:ED为35% (2-87%),CIS为45% (11-85%),SCC为50% (18-93%)(p = 0.007),并且在肩关节、下窝、下睑缘或跗骨受累时较高(p = 0.023)。侵犯眼球或眼眶的患者中位症状持续时间明显更长(6个月(0-48)vs 2个月(0-48); = 0.01页)。转移患者Ki-67 LI明显升高(p = 0.027)。结论:我们的研究发现,从首次出现症状到首次正确诊断的时间间隔延长与晚期SCC的高风险相关。此外,Ki-67 LI升高与侵袭性更强的肿瘤实体(如SCC和CIS)相关,表明转移风险增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ocular surface squamous cell neoplasia: risk factors for aggressive growth behaviour and the role of Ki-67.

Objective: Analyzing characteristics of ocular surface squamous cell neoplasia (OSSN) at first diagnosis and potential risk factors for aggressive growth behaviour.

Design: Retrospective.

Methods: Including patients with first diagnosis of OSSN at a tertiary center from 2013 until 2022. Cases were analyzed regarding demographics, clinical findings, and histopathological findings, including Ki-67 expression.

Results: A total of 153 patients with first diagnosis of histopathological confirmed OSSN were included. Mean age was 72 years (36-98), with a slight male predominance (66%; n = 101). Most patients had invasive squamous cell carcinoma (SCC; 45.8%, 70), followed by carcinoma in situ (CIS; 37.9%, 58) and epithelial dysplasia (ED; 16.3%, 25). Duration of symptoms varied significantly: ED 6 months (0-36), CIS 1.5 (0-48), SCC 3 (0-36) (p = 0.048). 44.3% (51/115) of cases were previously misdiagnosed, and, therefore, inadequately treated. Orbital involvement was observed in 8.5% (13), intraocular in 1.3% (2), metastasis in 2.7% (4) at initial diagnosis. Ki-67 labeling index (LI) varied significantly across subtypes: ED 35% (2-87%), CIS 45% (11-85%), SCC 50% (18-93%) (p = 0.007) and was higher with involvement of the caruncle, lower fornix, lower eyelid margin, or tarsus (p = 0.023). Patients with globe or orbit invasion had significantly longer median symptom duration (6 months (0-48) vs 2 (0-48); p = 0.01). Patients with metastasis exhibited significantly higher Ki-67 LI (p = 0.027).

Conclusions: Our study found extended time intervals from first symptoms to first correct diagnosis correlate with higher risk for advanced SCC. Further, elevated Ki-67 LI correlated with more invasive tumor entities, such as SCC and CIS, and indicate an increased risk of metastasis.

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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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