药物靶向内在无序蛋白和生物分子凝聚体的研究进展。

IF 4.4 1区生物学 Q1 BIOLOGY

BMC Biology Pub Date : 2025-05-06 DOI:10.1186/s12915-025-02214-x

Caolitao Qin, Yun-Long Wang, Jian Zheng, Xiang-Bo Wan, Xin-Juan Fan

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引用次数: 0

摘要

内在无序蛋白（IDPs）和生物分子凝聚物对细胞过程和生理功能至关重要。异常的生物分子凝聚物可导致癌症和神经退行性疾病等疾病。包括内在无序区（idr）在内的国内流离失所区，由于缺乏稳定的结合口袋，以前被认为是不可药物治疗的。然而，最近的证据表明，靶向它们可以影响细胞过程。这篇综述探讨了目前针对国内流离失所者和生物分子凝聚物的策略，潜在的改进，以及这一不断发展的领域的挑战和机遇。

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Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates.

Intrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders. IDPs, including intrinsically disordered regions (IDRs), were previously considered undruggable due to their lack of stable binding pockets. However, recent evidence indicates that targeting them can influence cellular processes. This review explores current strategies to target IDPs and biomolecular condensates, potential improvements, and the challenges and opportunities in this evolving field.

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来源期刊

BMC Biology 生物-生物学

CiteScore

7.80

自引率

1.90%

发文量

260

审稿时长

3 months

期刊介绍： BMC Biology is a broad scope journal covering all areas of biology. Our content includes research articles, new methods and tools. BMC Biology also publishes reviews, Q&A, and commentaries.