阿尔茨海默病星形细胞鸟氨酸脱羧酶1。

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Experimental Neurobiology Pub Date : 2025-04-30 Epub Date: 2025-04-11 DOI:10.5607/en25006

Mridula Bhalla, C Justin Lee

{"title":"阿尔茨海默病星形细胞鸟氨酸脱羧酶1。","authors":"Mridula Bhalla, C Justin Lee","doi":"10.5607/en25006","DOIUrl":null,"url":null,"abstract":"Recent research has shed light on the metabolic changes in reactive astrocytes associated with Alzheimer's disease, contributing to disease pathology. In this article, we summarize key findings related to reactive astrogliosis and how the discovery of the role of the enzyme ornithine decarboxylase 1 can set us on the path to finding more effective therapeutic strategies against neurodegenerative diseases.","PeriodicalId":12263,"journal":{"name":"Experimental Neurobiology","volume":"34 2","pages":"49-52"},"PeriodicalIF":1.8000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069927/pdf/","citationCount":"0","resultStr":"{\"title\":\"Astrocytic Ornithine Decarboxylase 1 in Alzheimer's Disease.\",\"authors\":\"Mridula Bhalla, C Justin Lee\",\"doi\":\"10.5607/en25006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent research has shed light on the metabolic changes in reactive astrocytes associated with Alzheimer's disease, contributing to disease pathology. In this article, we summarize key findings related to reactive astrogliosis and how the discovery of the role of the enzyme ornithine decarboxylase 1 can set us on the path to finding more effective therapeutic strategies against neurodegenerative diseases.\",\"PeriodicalId\":12263,\"journal\":{\"name\":\"Experimental Neurobiology\",\"volume\":\"34 2\",\"pages\":\"49-52\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069927/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Neurobiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5607/en25006\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Neurobiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5607/en25006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

最近的研究揭示了与阿尔茨海默病相关的反应性星形胶质细胞的代谢变化，有助于疾病病理。在本文中，我们总结了与反应性星形胶质细胞增生相关的关键发现，以及鸟氨酸脱羧酶1的作用的发现如何使我们找到更有效的治疗神经退行性疾病的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Astrocytic Ornithine Decarboxylase 1 in Alzheimer's Disease.

Recent research has shed light on the metabolic changes in reactive astrocytes associated with Alzheimer's disease, contributing to disease pathology. In this article, we summarize key findings related to reactive astrogliosis and how the discovery of the role of the enzyme ornithine decarboxylase 1 can set us on the path to finding more effective therapeutic strategies against neurodegenerative diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Experimental Neurobiology Neuroscience-Cellular and Molecular Neuroscience

CiteScore

4.30

自引率

4.20%

发文量

期刊介绍： Experimental Neurobiology is an international forum for interdisciplinary investigations of the nervous system. The journal aims to publish papers that present novel observations in all fields of neuroscience, encompassing cellular & molecular neuroscience, development/differentiation/plasticity, neurobiology of disease, systems/cognitive/behavioral neuroscience, drug development & industrial application, brain-machine interface, methodologies/tools, and clinical neuroscience. It should be of interest to a broad scientific audience working on the biochemical, molecular biological, cell biological, pharmacological, physiological, psychophysical, clinical, anatomical, cognitive, and biotechnological aspects of neuroscience. The journal publishes both original research articles and review articles. Experimental Neurobiology is an open access, peer-reviewed online journal. The journal is published jointly by The Korean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative Disease.